Condition

Higher-risk Myelodysplastic Syndromes clinical trials and research

• 5Clinical trials
• 14Countries

Newest Higher-risk Myelodysplastic Syndromes clinical trials

All recruiting trials (5)

• Bexmarilimab with Azacitidine vs Placebo with Azacitidine in Adults with Higher-Risk MDS

  This phase 2b study tests whether adding bexmarilimab to azacitidine helps adults with newly diagnosed higher-risk myelodysplastic syndromes compared with azacitidine alone.

  Recruiting Phase 2 Faron Pharmaceuticals Ltd · Duarte, California and 34 other locations · NCT07672769

• AZD3632, alone or with other anticancer agents, for advanced blood cancers driven by HOX overexpression

  This trial will test whether the oral drug AZD3632, given alone or with the antifungal posaconazole, is safe and helps control relapsed or refractory AML, ALL, or high-risk MDS that have KMT2A rearrangements, NPM1 mutations, or other genotypes causing HOX overexpression.

  Recruiting at 20 sites Phase 1/2 AstraZeneca · Decatur, Illinois and 29 other locations · NCT07155226

• Treatment for elderly patients with higher-risk myelodysplastic syndromes

  This study is testing a new treatment combining two medications followed by a stem cell transplant to see if it helps older patients with higher-risk myelodysplastic syndromes live longer and have fewer complications.

  Recruiting Phase 1/2 Navy General Hospital, Beijing · Beijing, Beijing Municipality · NCT06471946

• Investigating REM-422 for patients with higher risk MDS or relapsed AML

  This study is testing a new oral medication called REM-422 to see if it can help people with higher risk myelodysplastic syndromes or relapsed acute myeloid leukemia feel better and fight their cancer.

  Recruiting at 9 sites Phase 1 Remix Therapeutics · Duarte, California and 8 other locations · NCT06297941

• Evaluating AK117 with Azacitidine for higher-risk Myelodysplastic Syndromes

  This study is testing if a new treatment combining AK117 with azacitidine can help people recently diagnosed with higher-risk myelodysplastic syndromes feel better compared to standard treatment.

  Recruiting at 15 sites Phase 2 Akeso · Los Angeles, California and 14 other locations · NCT06196203

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Quick answers

How many Higher-risk Myelodysplastic Syndromes clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (4 trials), China (2 trials), France (2 trials), Italy (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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