Condition
HER2-positive clinical trials and research
As of November 12, 2026, Find a Trial lists 3 HER2-positive clinical trials that are recruiting, at sites in 2 countries (most in United States (2), China (1)). By phase: Phase 2 (2), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 2Countries
Newest HER2-positive clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| T-DXd–based therapy followed by targeted HER2 blockade and endocrine therapy in first-line HER2+ / HR+ metastatic breast cancer | Phase 3 | Columbia, Maryland and 4 other locations | Recruiting | Jul 6, 2026 |
| Trastuzumab and pertuzumab biosimilars with XELOX before surgery for HER2-positive rectal cancer | Phase 2 | Beijing | Recruiting | Aug 6, 2025 |
| Evaluating zanidatamab in early stage HER2-positive breast cancer | Phase 2 | Houston, Texas | Recruiting | Sep 5, 2021 |
All recruiting trials (3)
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T-DXd–based therapy followed by targeted HER2 blockade and endocrine therapy in first-line HER2+ / HR+ metastatic breast cancer
This trial tests a sequence of therapies starting with T-DXd plus pertuzumab, then a maintenance phase with dual HER2 blockade, endocrine therapy, and CDK4/6 inhibitor, with a retreatment option of T-DXd if disease progresses.
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Trastuzumab and pertuzumab biosimilars with XELOX before surgery for HER2-positive rectal cancer
This tests whether adding trastuzumab and pertuzumab biosimilars to XELOX chemotherapy before surgery can increase the complete tumor response in adults with locally advanced HER2-positive rectal cancer.
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Evaluating zanidatamab in early stage HER2-positive breast cancer
This study is testing if zanidatamab can help people with early stage HER2-positive breast cancer by seeing how well it shrinks tumors and checking for any side effects.
Related topics
Quick answers
How many HER2-positive clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (2 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.