Condition

Heart Failure and Reduced Ejection Fraction clinical trials and research

• 7Clinical trials
• 6Countries

Newest Heart Failure and Reduced Ejection Fraction clinical trials

All recruiting trials (7)

• Biomarkers linked to reverse heart healing in people with heart failure and reduced ejection fraction

  This study tests blood biomarkers and imaging data to see why some people with HFrEF improve their heart function after standard treatment.

  Recruiting Ruijin Hospital Luwan Branch · Shanghai, Shanghai Municipality · NCT07701876

• Selenium supplementation for people with heart failure

  This trial will test whether taking a daily selenium supplement helps people with heart failure avoid hospitalization and reduce the risk of death.

  Recruiting at 11 sites Phase 3 Skane University Hospital · Oslo and 10 other locations · NCT07543562

• How doctors’ reminders about iron treatment may change IV iron use in adults with heart failure

  This trial tests whether sending doctors reminders about iron deficiency guidelines helps them use IV iron more often in hospitalized adults with heart failure who are iron deficient.

  Recruiting Kaiser Permanente · Pleasanton, California · NCT07467668

• Comparing three specialist pacemakers to improve heart pumping and reduce rhythm problems

  This study will test three types of specialist pacemakers in people with heart failure and reduced ejection fraction to see which best improves symptoms and heart rhythms over six months.

  Recruiting Imperial College London · London, Greater London · NCT07430553

• Comparing cardiac contractility modulation (CCM) to usual care for people with reduced ejection fraction and NYHA class III heart failure

  This study tests whether cardiac contractility modulation (CCM) reduces deaths and heart failure hospital stays in Medicare‑eligible adults with NYHA class III heart failure and an ejection fraction of 25–45%.

  Recruiting Impulse Dynamics · Marlton, New Jersey · NCT07209098

• MitraClip for secondary (functional) mitral regurgitation with cardiac MRI scar measurement

  The study will try to see if the amount of scar (fibrosis) seen on cardiac MRI predicts left‑ventricular recovery and clinical outcomes after MitraClip in people with heart failure and reduced ejection fraction.

  Recruiting Minneapolis Heart Institute Foundation · Minneapolis, Minnesota and 5 other locations · NCT07131631

• Digital aid to help older adults with HFrEF decide about ICD placement.

  This project will test a web-based decision aid that provides personalized risk information to help older adults with heart failure and low ejection fraction decide whether to get an ICD.

  Recruiting at 2 sites Stanford University · San Francisco, California and 1 other locations · NCT07084142

Related topics

Quick answers

How many Heart Failure and Reduced Ejection Fraction clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), China (1 trial), Norway (1 trial), Sweden (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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