Condition

Advanced Hepatocellular Carcinoma (HCC) clinical trials and research

• 10Clinical trials
• 3Countries

Newest Advanced Hepatocellular Carcinoma (HCC) clinical trials

All recruiting trials (10)

• Dual-target GPC3 and B7-H3 CAR‑NK therapy for advanced liver cancer

  This trial will test an off‑the‑shelf CAR‑NK cell therapy that targets GPC3 and B7‑H3 in adults with advanced hepatocellular carcinoma who have progressed on or cannot take standard treatments.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07500220

• Super CAR-T therapy for GPC3-positive advanced liver cancer

  This trial tests a single infusion of Super CAR-T cell therapy in adults with advanced, GPC3-positive hepatocellular carcinoma who have failed at least two standard treatments.

  Recruiting Phase 1 Guangzhou FineImmune Biotechnology Co., LTD. · Guangzhou, Gaungdong · NCT07493044

• Comparing first-line immunotherapy combinations for advanced liver cancer

  We will try different first-line immunotherapy combinations to see which works best for people with advanced hepatocellular carcinoma.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07147101

• Autologous neoantigen T-cell therapy for advanced liver cancer

  This treatment tries a personalized neoantigen-specific T-cell therapy for people with advanced hepatocellular carcinoma who have not responded to two or more systemic treatments.

  Recruiting Phase 1/2 Zhejiang University · Hangzhou, Zhejiang · NCT07123545

• CG-102-12C for GPC3-positive advanced liver cancer

  This will test whether a single infusion of CG-102-12C can help people aged 18–75 with GPC3‑positive advanced hepatocellular carcinoma who did not respond to standard systemic treatments.

  Recruiting Zhejiang University · Hangzhou, Zhejiang and 1 other locations · NCT07039201

• Personalized mRNA therapy for advanced liver cancer

  This study is testing a new personalized mRNA therapy combined with other treatments to see if it can help people with advanced liver cancer feel better.

  Recruiting Phase 1/2 Zhejiang University · Hangzhou, Zhejiang · NCT06995105

• Multi-target Hi-TCR-T cell therapy for advanced hepatocellular carcinoma

  This trial will test whether personalized multi-target Hi-TCR-T cell infusions can help people with advanced, treatment-refractory hepatocellular carcinoma.

  Recruiting Phase 1/2 Eastern Hepatobiliary Surgery Hospital · Shanghai, Yangpu District · NCT06902389

• Comparing immunotherapy alone to immunotherapy with radiotherapy for advanced liver cancer

  This study is testing whether combining immunotherapy with radiation therapy can help people with advanced liver cancer feel better compared to just using immunotherapy alone.

  Recruiting at 2 sites Phase 2 National Cancer Center, Korea · Goyang and 1 other locations · NCT06828380

• Combination treatment for advanced liver cancer

  This study is testing a new combination of treatments for people with advanced liver cancer to see if it can help them respond better and live longer.

  Recruiting at 3 sites Phase 2 Sun Yat-sen University · Lanzhou, Gansu and 2 other locations · NCT06737913

• WGI-0301 plus sorafenib for advanced hepatocellular carcinoma

  This test tries whether adding the experimental IV drug WGI-0301 to standard oral sorafenib helps adults with advanced, unresectable hepatocellular carcinoma who have previously received PD‑1/PD‑L1 immunotherapy.

  Recruiting at 8 sites Phase 2 Zhejiang Haichang Biotech Co., Ltd. · Shanghai, Shanghai Municipality and 8 other locations · NCT06309485

Related topics

Quick answers

How many Advanced Hepatocellular Carcinoma (HCC) clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in China (9 trials), South Korea (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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