ZyMōt sperm selection method's effect on embryo quality
Official title: Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.
Run by Instituto Valenciano de Infertilidad, IVI VALENCIA · NCT06384794 · Data updated 2026-11-12
This study is testing a new way to select sperm to see if it can help couples undergoing IVF have better embryo quality and higher chances of pregnancy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Instituto Valenciano de Infertilidad, IVI VALENCIA Academic / other |
| Locations | 2 sites (Madrid and 1 other locations) |
| Status | Recruiting |
| Started | June 29, 2023 |
| Main results expected | July 1, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | April 29, 2024 |
| Trial ID | NCT06384794 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include couples undergoing ICSI with PGT-A, where the male partner is over 18 and has a suitable semen sample.
✕Probably not a fit
Patients with severe sperm motility issues, certain sperm morphological abnormalities, or those using donor oocytes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the ZyMōt Sperm Selection Method, which utilizes microfluidic technology to select sperm with lower DNA fragmentation without the use of centrifugation. It aims to improve fertilization rates and embryo development in couples undergoing ICSI with Preimplantational Genetic Testing for Aneuploidy (PGT-A). By comparing this method to conventional sperm selection techniques, the study seeks to determine its effectiveness in enhancing reproductive success. The study will involve fresh semen samples from eligible male participants and will monitor embryo development in a time-lapse incubator.
Why it matters
Potential benefit: If successful, this method could significantly improve embryo quality and increase the chances of successful pregnancies for couples facing infertility.
How similar studies have gone: While conventional sperm selection methods have shown success, the ZyMōt method is a novel approach that has not been extensively tested in clinical settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Couples undergoing an ICSI cycle with PGT-A (Preimplantational Genetic Test for Aneuploidy). * Males over 18 years of age whose semen sample meets the basic conditions predetermined by the ZyMōt Multi 850µL chip. * Fresh semen samples. * Embryos are to be deposited in a time-lapse incubator. * Women over 37 years of age who have obtained in follicular puncture a number of MII oocytes greater than or equal to 4. Exclusion Criteria: * Males with severe asthenozoospermia (\<10% progressively motile spermatozoa), globozoospermia (spermatozoa with morphological alterations and lack of acrosome) and/or azoospermia (absence of spermatozoa in the ejaculate). * Seminal samples obtained by testicular biopsy. * Samples incubated with calcium ionophore. * Males and females with previously known abnormal karyotype. * Oocytes coming from the oocyte donation program.
Where it's running
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Ivirma Madrid
Madrid, Spain Recruiting -
Ivirma Valencia
Valencia, Spain Recruiting
Study contacts
- Principal investigator: MARIA JOSE DE LOS SANTOS, PhD — IVIRMA Valencia
- Study coordinator: MARIA LUISA PARDIÑAS, Pre-Doc
- Email: marialuisa.pardiñas@ivirma.com
- Phone: +34 963.05.90.00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.