Zinc‑enhanced bovine hydroxyapatite for immediate dental implant grafting
Clinical and Radiographic Evaluation of Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant: A Randomized Clinical Study
NA · Suez Canal University · NCT07187609
This research will test whether adding zinc to a bovine-derived hydroxyapatite graft helps bone fill the gap around immediately placed dental implants in healthy adults.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 21 Years to 50 Years |
| Sex | All |
| Sponsor | Suez Canal University (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Suez) |
| Trial ID | NCT07187609 on ClinicalTrials.gov |
What this trial studies
This interventional comparison places dental implants immediately after tooth extraction and fills the peri-implant gap with either standard bovine-derived hydroxyapatite or the same material infused with zinc. Clinical and radiographic outcomes will be recorded to compare bone fill, implant stability, and local healing. Eligible participants are healthy adults with adequate ridge dimensions and a peri-implant gap larger than 1.5 mm in the mandible. Follow-up visits will include clinical exams and imaging to document changes over time.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 21–50 needing an immediately placed implant in the mandible with at least 6 mm ridge width, ≥3 mm subapical bone, an intact labial plate, and a peri-implant gap >1.5 mm.
Not a fit: Patients unlikely to benefit include smokers, those with uncontrolled systemic disease, pregnant or lactating women, immunocompromised patients, people undergoing chemo/radiotherapy, those with zinc allergy, or patients with parafunctional habits like bruxism.
Why it matters
Potential benefit: If successful, the zinc-enriched graft could improve bone fill and stability around immediate implants, potentially reducing resorption and improving implant success.
How similar studies have performed: Preclinical work and limited clinical reports suggest zinc-doped hydroxyapatite can enhance bone formation, but clinical evidence specifically for immediate implant gaps is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult(male or female) patients between the ages of 21 -50 years who requiring the replacement of one or more non-restorable teeth in the mandible which will be indicated for extraction. * Adequate bone dimensions at the implant site with ridge width of at least 6 mm, the availability of at least 3mm of sound subapical bone, the presence of an intact labial bone plate, and no evidance of periapical infection on cone beam computed tomography or clinically * The peri-implant gaps larger than 1.5 mm will be included. * All patients will be physically healthy with no medical history of any systemic disease. Exclusion Criteria: * Smokers. * Patients with para functional habits such as bruxism and clenching * Poorly controlled systemic diseases which preclude local anesthesia or surgical procedures * Patients undergoing chemotherapy or radiotherapy and immuno-compromised patients. * Pregnant /lactating women. * Patients that are allergic to zinc * Patients on antibiotic therapy in the pervious 6 months
Where this trial is running
Suez
- Suez canal university — Suez, Egypt (RECRUITING)
Study contacts
- Study coordinator: Ibrahim Montaser, General Dental Practitioner
- Email: pgs.230046@dent.suez.edu.eg
- Phone: 0 10 66189289
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Implant, Zinc Status, bone grafts, zinc in corporated bovine drived hydroxyappatite