Zinc vs. Folic Acid for Lowering Homocysteine in Kidney Patients on Dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of zinc supplementation compared to folic acid in reducing hyperhomocysteinemia in patients with chronic kidney disease undergoing hemodialysis. Hyperhomocysteinemia is a significant risk factor for cardiovascular events in these patients. The study will randomly assign ninety participants to receive either zinc sulfate or folic acid over a period of one and a half years at Chittagong Medical College Hospital in Bangladesh. The aim is to determine if zinc can provide a more effective solution for managing elevated homocysteine levels in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Age ≥18 years 2. Patient with chronic kidney disease on HD for ≥ 3 months 3. Plasma homocysteine level \> 15μmol/L

Exclusion Criteria:

1. Acute illness at the time of inclusion.
2. Diagnosed case of malabsorption
3. Planned major surgery
4. Renal transplantation
5. Receiving zinc or folic acid supplementation within the previous month from enrollment.
6. Concomitant use of vitamin B 12 supplementation(6 days), corticosteroid (18-36 hour), anti folate or cytotoxic drugs, quinolones, tetracyclines, bisphosphonates.
7. Known hypersensitivity to zinc or folic acid.

   \-

Where it's running

• Chittagong Medical College
  Chittagong, Bangladesh Recruiting

Study contacts

• Study coordinator: Md Zakwan Ullah
• Email: zakwan.cmc@gmail.com
• Phone: +8801680560222

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Renal rehabilitation with low-dialysate-flow daily hemodialysis for people on hemodialysis

  This tests whether combining a tailored rehab program (exercise + nutrition) with low-dialysate-flow daily hemodialysis helps people on hemodialysis who are at risk of muscle loss (sarcopenia).

  Recruiting Brugmann University Hospital · Brussels · NCT07413315

• Aerobic versus resistance exercise during hemodialysis to change the atherogenic index

  This trial will test whether doing aerobic or resistance exercise during dialysis can change the atherogenic index in adults on maintenance hemodialysis aged 40–60.

  Recruiting Cairo University · Cairo, Select State and 1 other locations · NCT07045064

• End-to-side versus Piggyback anastomosis to create arteriovenous fistulas for hemodialysis

  This trial will test whether the piggyback (pSLOT) or the traditional end-to-side surgical technique produces more reliable arteriovenous fistulas for adults with advanced chronic kidney disease who need hemodialysis.

  Recruiting Hospital Clinic of Barcelona · Barcelona, Barcelona · NCT06997042

• Technology-assisted stepped collaborative care for pain, fatigue, and depression in dialysis patients

  This trial tests whether a technology-assisted stepped collaborative care program — combining medications and/or cognitive behavioral therapy delivered with dialysis staff support and telemedicine — can reduce pain, fatigue, and depression in adults on in-center hemodialysis.

  Recruiting at 2 sites University of Pittsburgh · Albuquerque, New Mexico and 1 other locations · NCT06978127

• Structured exercise program to improve arteriovenous fistula maturation for hemodialysis in chronic kidney disease patients

  This study is testing whether a special exercise program can help improve the success of arteriovenous fistulas in patients with chronic kidney disease who are getting ready for hemodialysis.

  Recruiting Unidade Local de Saúde de Coimbra, EPE · Coimbra, Coimbra District · NCT06960304

• Effects of SGLT2 inhibitors on heart health in hemodialysis patients

  This study is testing if a new type of diabetes medication can improve heart health in patients with kidney failure who are on hemodialysis.

  Recruiting Phase 2 Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno · Buenos Aires, Buenos Aires · NCT06929169

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.