ZG006 plus PD‑1/PD‑L1 immunotherapy as first‑line treatment for extensive‑stage small cell lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, multicenter phase 1b trial combines the experimental agent ZG006 with PD‑1/PD‑L1 immune checkpoint inhibitors (including serplulimab) with or without chemotherapy as first‑line therapy for extensive‑stage small cell lung cancer. It enrolls adults aged 18–75 with histologically or cytologically confirmed ES‑SCLC, ECOG performance status 0–1, and life expectancy of at least 3 months. The primary focus is on safety and tolerability, with exploratory efficacy endpoints such as response rate and progression‑free survival. Participants are randomized to receive the combination regimen and undergo scheduled clinical assessments and imaging per protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants with histologically or cytologically confirmed ES-SCLC.
* Fully understand the study and voluntarily sign the informed consent form;
* Male or female 18\~75 years of age;
* Eastern Cooperative Oncology Group(ECOG) Performance Status of 0 or 1;
* Life expectancy ≥ 3 months;

Exclusion Criteria:

* Participants were deemed unsuitable for participating in the study by the investigator for any reason.

Where it's running

• Shanghai Chest Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Cong Zhang
• Email: zhangc@zelgen.com
• Phone: 17602176888

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.