Zanubrutinib plus rituximab as first-line treatment for marginal zone lymphoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-arm, multi-center real-world observational study using the combination of zanubrutinib and rituximab (ZR) in the first-line setting for marginal zone lymphoma (MZL). Eligible patients are treatment‑naïve, CD20‑positive, and have at least one measurable lesion by imaging. Patients receive zanubrutinib plus rituximab and are followed for clinical response and adverse events under routine clinical conditions without randomization. The study aims to capture efficacy and safety outcomes in a practice-based population to complement data from controlled trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with CD20-positive marginal zone lymphoma diagnosed by histopathology
2. First-line treatment with the combination regimen of zanubrutinib and rituximab
3. No receiving systematic treatment before enrollment
4. Having at least one measurable lesions. Measurable lesions were defined as: the longest diameter of lymph node lesions in CT cross-sectional images \> 1.5 cm, or the longest diameter of the extranodal lesion is greater than 1.0cm
5. The patients voluntarily joined this study, signed the informed consent form, had good compliance and cooperated with the follow-up.

Exclusion Criteria:

1. Other malignant tumor history or active malignant tumor need be treated
2. In addition to zanubrutinib and rituximab, other anti-tumor drug treatments were also received simultaneously (except for glucocorticoids aimed at controlling symptoms before formal treatment).

Where it's running

• Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university
  Zhengzhou, Henan, China Recruiting

Study contacts

• Study coordinator: Zhihua Yao, M.D. Ph.D
• Email: zlyyyaozhihua1260@zzu.edu.cn
• Phone: +8613592622292

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.