Xiangya Heart and Lung Health and Disease Cohort

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a bidirectional cohort that combines retrospective hospital records and prospective follow-up to create a comprehensive cardiopulmonary dataset. Retrospective data include electronic medical records, imaging, and cardiopulmonary function tests from Xiangya Hospital covering January 2010 to April 2025. Patients with paired cardiac and pulmonary function measures will be invited into a prospective arm for at least three years of dynamic monitoring across resting, exercise, and sleep scenarios. The project aims to define core indicators of cardiopulmonary hypofunction, develop a joint stratification system, and map comorbidity patterns to link functional profiles with long-term outcomes.

Why it matters

Who can join: the full rules

I1 Inclusion and exclusion criteria for retrospective cohorts 1) Inclusion criteria:

1. Patients were either treated or hospitalized in the physical examination center, outpatient and emergency clinic in the Xiangya Hospital of Central South University from January 2010 to April 2025.
2. Completion of cardiac function (e.g., echocardiography) and pulmonary function (e.g., pulmonary function test) assessment, with an interval of no more than 1 year between the two.
3. Those who had complete clinical diagnostic and therapeutic information (e.g., medical history, medication records, laboratory test results, imaging reports) except for the cardiopulmonary function test report.

2)Exclusion criteria

1. Patients with complete loss of cardiopulmonary function test reports or key data (e.g., VO2peak, FEV1/FVC, LVEF).
2. Patients with loss of key clinical diagnostic and treatment data (e.g., medical history, medication records, laboratory test results).

2.1.2 Inclusion and exclusion criteria for prospective cohort

1）Inclusion criteria

1. Patients who have been included in the retrospective cohort.
2. Voluntarily signed informed consent form to participate in long-term follow-up for ≥3 years.
3. Able to complete the baseline assessment of the prospective cohort (including cardiopulmonary function retesting, questionnaires, etc.).
4. Stable conditions for follow-up (e.g., living in the local area, available valid contact information, no plans to move in the short term or go out for a long period of time).

2\) Exclusion Criteria.

1. Patients who have been excluded from the retrospective cohort or for whom key data are missing.
2. With severe cognitive impairment, psychiatric disease or verbal communication disorder, unable to cooperate with follow-up and data collection.
3. Expected survival time \<3 years (e.g., advanced malignancy, end-stage cardiopulmonary failure, etc.).
4. Incomplete cardiopulmonary function or other clinical data during the baseline assessment.
5. Those who plan to participate in other interventional clinical trials that may interfere with the assessment of cardiopulmonary function.

Where it's running

• Xiangya Hospital, Central South University Affiliated
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: yuan zhang, PhD
• Email: zhangyuan9194@163.com
• Phone: 86-0731-84327029

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.