Xiangya Heart and Lung Health and Disease Cohort

Xiangya Cardiopulmonary Health and Disease Cohort

See if patterns of heart and lung function during rest, exercise, and sleep predict long-term outcomes in people with or without cardiopulmonary disease.

Quick facts

• Study type: Observational
• Enrollment: 30000 (estimated)
• Sex: All
• Sponsor: Xiangya Hospital of Central South University (Academic / other)
• Locations: 1 site (Changsha, Hunan)
• Trial ID: NCT06972784 on ClinicalTrials.gov

What this trial studies

This is a bidirectional cohort that combines retrospective hospital records and prospective follow-up to create a comprehensive cardiopulmonary dataset. Retrospective data include electronic medical records, imaging, and cardiopulmonary function tests from Xiangya Hospital covering January 2010 to April 2025. Patients with paired cardiac and pulmonary function measures will be invited into a prospective arm for at least three years of dynamic monitoring across resting, exercise, and sleep scenarios. The project aims to define core indicators of cardiopulmonary hypofunction, develop a joint stratification system, and map comorbidity patterns to link functional profiles with long-term outcomes.

Who should consider this trial

Good fit: Adults treated at Xiangya Hospital who have completed both cardiac and pulmonary function tests within one year of each other and who can consent to long-term follow-up are ideal candidates.

Not a fit: People without paired heart and lung function tests, with missing key clinical data, or who cannot attend follow-up visits are unlikely to benefit from this cohort.

Why it matters

Potential benefit: If successful, this could help clinicians detect combined heart–lung dysfunction earlier and better predict which patients are at higher risk, enabling more personalized care.

How similar studies have performed: Previous studies have linked individual cardiac or pulmonary measures to outcomes, but comprehensive longitudinal cohorts that integrate rest, exercise, and sleep data are relatively novel.

Eligibility criteria

I1 Inclusion and exclusion criteria for retrospective cohorts 1) Inclusion criteria:

1. Patients were either treated or hospitalized in the physical examination center, outpatient and emergency clinic in the Xiangya Hospital of Central South University from January 2010 to April 2025.
2. Completion of cardiac function (e.g., echocardiography) and pulmonary function (e.g., pulmonary function test) assessment, with an interval of no more than 1 year between the two.
3. Those who had complete clinical diagnostic and therapeutic information (e.g., medical history, medication records, laboratory test results, imaging reports) except for the cardiopulmonary function test report.

2)Exclusion criteria

1. Patients with complete loss of cardiopulmonary function test reports or key data (e.g., VO2peak, FEV1/FVC, LVEF).
2. Patients with loss of key clinical diagnostic and treatment data (e.g., medical history, medication records, laboratory test results).

2.1.2 Inclusion and exclusion criteria for prospective cohort

1）Inclusion criteria

1. Patients who have been included in the retrospective cohort.
2. Voluntarily signed informed consent form to participate in long-term follow-up for ≥3 years.
3. Able to complete the baseline assessment of the prospective cohort (including cardiopulmonary function retesting, questionnaires, etc.).
4. Stable conditions for follow-up (e.g., living in the local area, available valid contact information, no plans to move in the short term or go out for a long period of time).

2\) Exclusion Criteria.

1. Patients who have been excluded from the retrospective cohort or for whom key data are missing.
2. With severe cognitive impairment, psychiatric disease or verbal communication disorder, unable to cooperate with follow-up and data collection.
3. Expected survival time \<3 years (e.g., advanced malignancy, end-stage cardiopulmonary failure, etc.).
4. Incomplete cardiopulmonary function or other clinical data during the baseline assessment.
5. Those who plan to participate in other interventional clinical trials that may interfere with the assessment of cardiopulmonary function.

Where this trial is running

Changsha, Hunan

• Xiangya Hospital, Central South University Affiliated — Changsha, Hunan, China (Recruiting)

Study contacts

• Study coordinator: yuan zhang, PhD

Conditions Respiratory Function Tests，Heart Function Tests; Cardiopulmonary Function; Respiratory function tests，Heart Function Tests，Cardiopulmonary function