Wrap therapy to reduce body and scalp discomfort in hereditary ichthyosis
Official title: Evaluate the Evolution of Cutaneous Discomfort of the Body and Scalp After 3 Wraps, in Patients With Moderate to Very Severe Hereditary Ichthyosis
Run by University Hospital, Toulouse · NCT05979506 · Data updated 2026-11-12
This project will try nurse‑applied wraps — heavy emollient and keratolytic creams applied after a therapeutic bath and covered for a period of occlusion — to see if they reduce skin discomfort and scaling for people with hereditary ichthyosis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | All |
| Enrollment | 34 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Status | Recruiting |
| Started | February 2, 2024 |
| Main results expected | October 10, 2026 |
| Study ends | October 10, 2026 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT05979506 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People with hereditary ichthyosis who have moderate-to-severe scaling or redness (score >6/16) and at least moderate skin discomfort (>3/10), can give informed consent, and can complete questionnaires are the intended candidates.
✕Probably not a fit
Patients with other skin diseases, recent changes in ichthyosis treatments, known allergies to the topical agents used, those unable to complete study questionnaires, or those under legal protection are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single‑center interventional study tests the short- and medium‑term effects of cutaneous wraps performed by specialized nurses at Toulouse University Hospital. After a therapeutic bath, large amounts of tailored creams are applied to the body, feet, and scalp and then occluded, with scalp care including steam helmet exposure to help scale removal. Outcomes include measures of scaling, erythema, and patient‑reported skin discomfort collected before and after wrap treatments. Participants must have hereditary ichthyosis with at least moderate scaling/erythema and discomfort and be able to consent and complete questionnaires.
Why it matters
Potential benefit: If successful, wraps could meaningfully reduce skin pain, itching and visible scaling, improving daily comfort and ease of skin care.
How similar studies have gone: Nurse‑administered occlusive wrap techniques have shown symptomatic benefit in small case series and clinical experience, but robust controlled evidence in hereditary ichthyosis is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with hereditary ichthyosis regardless of the clinical form * Patient with a scaling or erythema score \> 6/16 * Patient with a skin discomfort score \> 3/10 * Patient having given written, free and informed consent * Patient affiliated to a social security scheme Exclusion Criteria: * Patient with a skin disease other than ichthyosis * Patient having modified his treatments for ichthyosis in the month preceding inclusion * Patient with known intolerance or allergy to one of the topicals used in the study * Patient unable to complete the study questionnaires * Patient under a protection regime
Where it's running
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Toulouse University hospital
Toulouse, France Recruiting
Study contacts
- Principal investigator: Anne-Marie TRANIER — University Hospital, Toulouse
- Study coordinator: Anne-Marie TRANIER
- Email: tranier.am@chu-toulouse.fr
- Phone: 05 67 77 14 57
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.