Wrap therapy to reduce body and scalp discomfort in hereditary ichthyosis
Evaluate the Evolution of Cutaneous Discomfort of the Body and Scalp After 3 Wraps, in Patients With Moderate to Very Severe Hereditary Ichthyosis
NA · University Hospital, Toulouse · NCT05979506
This project will try nurse‑applied wraps — heavy emollient and keratolytic creams applied after a therapeutic bath and covered for a period of occlusion — to see if they reduce skin discomfort and scaling for people with hereditary ichthyosis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 34 (estimated) |
| Ages | 15 Years and up |
| Sex | All |
| Sponsor | University Hospital, Toulouse (other) |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT05979506 on ClinicalTrials.gov |
What this trial studies
This single‑center interventional study tests the short- and medium‑term effects of cutaneous wraps performed by specialized nurses at Toulouse University Hospital. After a therapeutic bath, large amounts of tailored creams are applied to the body, feet, and scalp and then occluded, with scalp care including steam helmet exposure to help scale removal. Outcomes include measures of scaling, erythema, and patient‑reported skin discomfort collected before and after wrap treatments. Participants must have hereditary ichthyosis with at least moderate scaling/erythema and discomfort and be able to consent and complete questionnaires.
Who should consider this trial
Good fit: People with hereditary ichthyosis who have moderate-to-severe scaling or redness (score >6/16) and at least moderate skin discomfort (>3/10), can give informed consent, and can complete questionnaires are the intended candidates.
Not a fit: Patients with other skin diseases, recent changes in ichthyosis treatments, known allergies to the topical agents used, those unable to complete study questionnaires, or those under legal protection are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, wraps could meaningfully reduce skin pain, itching and visible scaling, improving daily comfort and ease of skin care.
How similar studies have performed: Nurse‑administered occlusive wrap techniques have shown symptomatic benefit in small case series and clinical experience, but robust controlled evidence in hereditary ichthyosis is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with hereditary ichthyosis regardless of the clinical form * Patient with a scaling or erythema score \> 6/16 * Patient with a skin discomfort score \> 3/10 * Patient having given written, free and informed consent * Patient affiliated to a social security scheme Exclusion Criteria: * Patient with a skin disease other than ichthyosis * Patient having modified his treatments for ichthyosis in the month preceding inclusion * Patient with known intolerance or allergy to one of the topicals used in the study * Patient unable to complete the study questionnaires * Patient under a protection regime
Where this trial is running
Toulouse
- Toulouse University hospital — Toulouse, France (RECRUITING)
Study contacts
- Principal investigator: Anne-Marie TRANIER — University Hospital, Toulouse
- Study coordinator: Anne-Marie TRANIER
- Email: tranier.am@chu-toulouse.fr
- Phone: 05 67 77 14 57
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ichthyosis Inherited, Ichthyosis, inherited, wraps, skin scales, cutaneous abnormalities