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Clinical trial Recruiting at 2 sites Observational Ages 18 to 80

Why multiple brain aneurysms become unstable using high‑resolution MRI, imaging histology, and blood‑flow analysis

Official title: Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics

Run by Zhujiang Hospital · NCT06539767 · Data updated 2026-11-12

This project will try to identify imaging, blood‑pressure, and blood‑flow features that predict instability in adults (18–80) with multiple intracranial aneurysms who are candidates for endovascular treatment.

Quick facts

Study typeObservational
Ages18 Years to 80 Years
SexAll
Enrollment1000 (estimated)
SponsorZhujiang Hospital
Academic / other
Locations2 sites (Guangzhou, Guangdong and 1 other locations)
StatusRecruiting
StartedJanuary 1, 2023
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedJuly 28, 2025
Trial IDNCT06539767 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–80 with diagnosed intracranial aneurysms (multiple) who are suitable for endovascular treatment, willing to undergo high‑resolution MRI and scheduled follow‑up, and able to give informed consent.

Probably not a fit

Patients with AVM, Moyamoya disease, or DAVF‑related aneurysms, those with contraindications to high‑resolution MRI, severe comorbidities precluding procedures, or poor compliance are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort built on a preexisting multicenter multiple intracranial aneurysm (MIA) database. Participants will receive high‑resolution magnetic resonance imaging to detect aneurysm wall enhancement, noninvasive hemodynamic modeling from vascular imaging, ambulatory blood pressure monitoring, and imaging histology when available. Clinical and imaging biomarkers will be collected and patients followed over time to link these measures with aneurysm instability, growth, or clinical events. The study focuses on patients eligible for endovascular treatment and does not introduce investigational therapies.

Why it matters

Potential benefit: If successful, the project could help doctors predict which aneurysms are likely to become unstable so treatment can be targeted to prevent rupture.

How similar studies have gone: Prior work has shown aneurysm wall enhancement on HRMRI and hemodynamic measures can indicate instability, but prospectively combining HRMRI, imaging histology, ambulatory blood pressure, and hemodynamics in a multicenter MIA cohort is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age 18-80 years old, male or infertile female;
* Diagnosed as IA (intracranial aneurysm) through CTA, MRA, or DSA; And it is suitable for endovascular intervention treatment
* The patient and/or their legal representative or guardian fully understand the research purpose, voluntarily participate and sign informed consent Books;
* Patients willing to cooperate with high-resolution magnetic resonance imaging.
* Patients willing to follow up and evaluate according to clinical research protocol requirements

Exclusion Criteria:

* AVM (arteriovenous malformation), Moyamoya disease, or DAVF (dural arteriovenous fistula) related aneurysms;
* Patients with contraindications for high-resolution magnetic resonance imaging;
* Participants in clinical trials of other drugs or medical devices;
* Patients with severe underlying diseases and extremely poor clinical conditions who cannot tolerate general anesthesia surgery;
* Patients with poor compliance and inability to cooperate with follow-up;
* Possible or clear history of severe allergy to contrast agents;
* Patients with a life expectancy of less than 2 years;
* Women who are breastfeeding and preparing for pregnancy during the study period

Where it's running

  • Zhujiang Hospital
    Guangzhou, Guangdong, China     Recruiting
  • Southern medical university, zhujiang hospital
    Guangzhou, China     Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.