Why multiple brain aneurysms become unstable using high‑resolution MRI, imaging histology, and blood‑flow analysis
Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics
This project will try to identify imaging, blood‑pressure, and blood‑flow features that predict instability in adults (18–80) with multiple intracranial aneurysms who are candidates for endovascular treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 2 sites (Guangzhou, Guangdong and 1 other locations) |
| Trial ID | NCT06539767 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational cohort built on a preexisting multicenter multiple intracranial aneurysm (MIA) database. Participants will receive high‑resolution magnetic resonance imaging to detect aneurysm wall enhancement, noninvasive hemodynamic modeling from vascular imaging, ambulatory blood pressure monitoring, and imaging histology when available. Clinical and imaging biomarkers will be collected and patients followed over time to link these measures with aneurysm instability, growth, or clinical events. The study focuses on patients eligible for endovascular treatment and does not introduce investigational therapies.
Who should consider this trial
Good fit: Adults 18–80 with diagnosed intracranial aneurysms (multiple) who are suitable for endovascular treatment, willing to undergo high‑resolution MRI and scheduled follow‑up, and able to give informed consent.
Not a fit: Patients with AVM, Moyamoya disease, or DAVF‑related aneurysms, those with contraindications to high‑resolution MRI, severe comorbidities precluding procedures, or poor compliance are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the project could help doctors predict which aneurysms are likely to become unstable so treatment can be targeted to prevent rupture.
How similar studies have performed: Prior work has shown aneurysm wall enhancement on HRMRI and hemodynamic measures can indicate instability, but prospectively combining HRMRI, imaging histology, ambulatory blood pressure, and hemodynamics in a multicenter MIA cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-80 years old, male or infertile female; * Diagnosed as IA (intracranial aneurysm) through CTA, MRA, or DSA; And it is suitable for endovascular intervention treatment * The patient and/or their legal representative or guardian fully understand the research purpose, voluntarily participate and sign informed consent Books; * Patients willing to cooperate with high-resolution magnetic resonance imaging. * Patients willing to follow up and evaluate according to clinical research protocol requirements Exclusion Criteria: * AVM (arteriovenous malformation), Moyamoya disease, or DAVF (dural arteriovenous fistula) related aneurysms; * Patients with contraindications for high-resolution magnetic resonance imaging; * Participants in clinical trials of other drugs or medical devices; * Patients with severe underlying diseases and extremely poor clinical conditions who cannot tolerate general anesthesia surgery; * Patients with poor compliance and inability to cooperate with follow-up; * Possible or clear history of severe allergy to contrast agents; * Patients with a life expectancy of less than 2 years; * Women who are breastfeeding and preparing for pregnancy during the study period
Where this trial is running
Guangzhou, Guangdong and 1 other locations
- Zhujiang Hospital — Guangzhou, Guangdong, China (Recruiting)
- Southern medical university, zhujiang hospital — Guangzhou, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.