Whole-food beef protein and amino acid oxidation in young adults
Official title: Amino Acid Oxidation of Whole-Food Protein: a Dose-Response Crossover Trial in Young Adults
Run by Maastricht University Medical Center · NCT07547176 · Data updated 2026-11-12
This test will see how three dinner doses of minced beef affect 24-hour amino acid oxidation in healthy 18–35-year-olds.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht, Limburg) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT07547176 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy males and females aged 18–35 with BMI 18.5–30 kg/m2 who are recreationally active, consume beef, and are not taking medications that affect protein metabolism are ideal candidates.
✕Probably not a fit
People who are vegan or vegetarian, smokers, pregnant women, those with diagnosed GI disorders, or those taking medications that affect protein metabolism are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In a randomized crossover design, 20 healthy young adults (ages 18–35) consume dinners providing 0.32, 0.74, and 1.32 g protein·kg body mass−1 (equivalent to 1, 2, and 4 minced beef patties) across three separate experimental visits. Amino acid oxidation from the ingested protein is measured over a 24-hour period after each meal. Participants serve as their own controls so dose-response relationships can be compared within individuals. The study focuses on whole-food protein (minced beef) rather than isolated protein supplements.
Why it matters
Potential benefit: If successful, the results could help define practical whole-food protein portions that reduce amino acid waste and inform dietary protein recommendations for young adults.
How similar studies have gone: Prior dose-response studies using isolated proteins and mixed meals have shown dose-dependent amino acid oxidation, but comparable data using whole-food beef are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18-35 years * BMI between 18.5-30 kg/m2 * Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week) * No physical limitations (i.e., able to perform all activities associated with daily living independently) Exclusion Criteria: * Smoking * Vegan, vegetarian, or does not consume beef protein * Diagnosed musculoskeletal disorders * Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications) * Chronic use of gastric acid-suppressing medication or anti-coagulants * Unstable weight over the last three months * Diagnosed GI tract disorders or diseases * Blood donation in the past 2 months * Females: pregnancy
Where it's running
-
Maastricht University Medical Centre+
Maastricht, Limburg, Netherlands Recruiting
Study contacts
- Principal investigator: Luc JC van Loon, PhD — Maastricht University
- Study coordinator: Julia M Malowany, MSc
- Email: julia.malowany@maastrichtuniversity.nl
- Phone: +31 43 388 1617
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.