Whole body skin wetting for burn survivors
Skin Wetting in Burn Survivors
This study tests if wetting the skin can help burn survivors stay cooler during exercise in hot conditions.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06529757 on ClinicalTrials.gov |
What this trial studies
This project investigates the effectiveness of whole body skin wetting to reduce internal body temperature spikes during exercise in well-healed burn survivors. The study employs a randomized crossover design, comparing the effects of cooling versus non-cooling interventions. Participants include burn survivors with varying degrees of burn coverage and non-burned control subjects. The study aims to assess how these interventions impact physical activity in heated environments.
Who should consider this trial
Good fit: Ideal candidates include healthy burn survivors aged 18-65 with burn injuries covering 20-40% or more than 40% of their body surface area.
Not a fit: Patients with underlying medical conditions, those who have experienced significant burn-related hospitalization, or non-burned individuals may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could help burn survivors manage their body temperature better during physical activity, improving their overall exercise tolerance and quality of life.
How similar studies have performed: While this approach is innovative, similar studies focusing on temperature regulation in burn survivors have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Non-burn survivors * Healthy male and female subjects * 18-65 years of age. * Free of any underlying medical conditions Exclusion Criteria (non-burned individuals): * Any burn-related injuries resulting in at least one night of hospitalization. * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension. * Abnormalities detected on routine screening * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2. * Pregnant individuals Inclusion Criteria (burn survivors): * Healthy male and female subjects * 18-65 years of age. * Free of any underlying medical conditions * Having a burn injury covering 20-40% or \>40% of the participant's body surface area; at least 50% of those burn injuries must be full thickness that required skin grafting. * Participants must have been hospitalized due to the burn injury for a minimum of 15 days Exclusion Criteria (burn survivors): * Any burn-related injuries resulting in at least one night of hospitalization. * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension. * Abnormalities detected on routine screening * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2. * Pregnant individuals * Extensive unhealed injured skin
Where this trial is running
Dallas, Texas
- Institute for Exercise and Environmental Medicine — Dallas, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Craig Crandall, PhD
- Email: craigcrandall@texashealth.org
- Phone: 214-345-4623
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.