Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Who should lead hospital rapid response teams?

Official title: Rapid Response Teams - How and Who? A Randomized Controlled Trial Examining the Composition of the RRT in a General Hospital

Run by Nordsjaellands Hospital · NCT04507737 · Data updated 2026-11-12

This trial will test whether a Critical Care Outreach Team led by an ICU nurse plus ward clinicians works as well as a Medical Emergency Team led by an ICU doctor for adult patients on general wards who need rapid response care.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1500 (estimated)
SponsorNordsjaellands Hospital
Academic / other
Locations1 site (Hillerød, Danmark)
StatusRecruiting
StartedSeptember 1, 2021
Main results expectedDecember 30, 2025
Study endsJanuary 31, 2026
Registry record updatedSeptember 17, 2025
Trial IDNCT04507737 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age 18 and over) admitted to general hospital wards who require a rapid response team call are eligible candidates.

Probably not a fit

Patients in delivery, anesthetic department areas (ICU, HDU, post-op, operating theatre, same-day surgery), those not admitted at the time of the call (ED evaluation, outpatients, imaging), or those who cannot be randomized at the time of call are not expected to benefit from this trial.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a one-sided blinded, locally randomized trial comparing two rapid response team compositions: a Critical Care Outreach Team (ICU nurse plus a general ward physician and nurse) versus a Medical Emergency Team (ICU doctor plus ICU nurse and ward clinician). Adult patients on general wards who trigger an RRT call are randomized 1:1 at the time of the call using a centrally generated sequence implemented with sealed opaque envelopes. Primary outcomes will be analyzed in the intention-to-treat population, with secondary outcomes analyzed per-protocol excluding protocol violations. Investigators are blinded to allocation, although responding clinicians cannot be blinded to which team attends.

Why it matters

Potential benefit: If successful, a nurse-led CCOT could provide care comparable to doctor-led METs while freeing intensive care physicians for other critical duties and improving resource use.

How similar studies have gone: Previous studies of varied rapid response team compositions, including nurse-led outreach models, have shown mixed but sometimes promising results, so the approach has partial precedent but is not definitively settled.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Admitted to any general ward of the hospital AND
* Aged ≥ 18 years AND
* In need of RRT attention

Exclusion Criteria:

* Age \< 18
* Admitted to the delivery ward
* Admitted to any ward in the anesthetic department

  * ICU
  * High Dependency Unit
  * Post Operation Department
  * Operating Theatre
  * Same Day Admissions - Surgery Ward
* Not admitted at the time of call

  * Evaluation track in Emergency department (prior to being seen by a doctor)
  * Out-Patient departments
  * X-ray department
* Any patient who cannot be randomized at the time of call

Where it's running

  • Nordsjællands Hospital
    Hillerød, Danmark, Denmark
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.