Which material for All-on-Four implants? Zantex vs Zirconia in full-arch dentures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, researchers compare two framework materials—Zantex and Zirconia—for mandibular hybrid prostheses supported by four implants using the All-on-Four concept. Microbial adhesion on retrieved prosthesis frameworks and peri-implant tissue health are measured over a 3-month follow-up. Clinical parameters include plaque, bleeding on probing, and probing depth at multiple time points (1 week, 2 weeks, 1 month, and 3 months). Fourteen participants (7 per group) will be enrolled to achieve 90% power. The study aims to inform material choice to support oral health in full-arch implant restorations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Completely edentulous patients in the mandibular arch.
2. Patients with a completely edentulous maxillary arch rehabilitated with a conventional complete denture.
3. Patients with sufficient mandibular bone volume and quality to allow placement of four implants according to the All-on-Four treatment concept.
4. Patients suitable for placement of two axial anterior implants in the canine regions and two distally tilted posterior implants anterior to the mental foramina.
5. Patients with adequate restorative space to accommodate a full-arch hybrid prosthesis.
6. Patients who are willing and able to maintain adequate oral hygiene and attend all scheduled follow-up appointments.
7. Patients who are willing to participate in the study and sign the informed consent form.

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Exclusion Criteria:

* 1\. Patients with systemic conditions that contraindicate implant surgery or may adversely affect osseointegration or wound healing.

  2\. Patients receiving medications or undergoing treatments that significantly affect bone metabolism or healing.

  3\. Patients with a history of radiotherapy involving the head and neck region that may compromise implant therapy.

  4\. Patients with active or uncontrolled periodontal or oral infections. 5. Patients with inadequate mandibular bone volume or unfavorable anatomical conditions that prevent placement of four implants according to the planned All-on-Four protocol without additional augmentation procedures.

  6\. Patients with severe parafunctional habits, such as uncontrolled bruxism, that may compromise the prosthetic rehabilitation.

  7\. Patients unable or unwilling to maintain appropriate oral hygiene. 8. Patients unable to attend the scheduled follow-up visits. 9. Patients who decline to participate or fail to provide informed consent

Where it's running

• Faculty of Dentistry, Kafrelsheikh University
  Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt Recruiting

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.