Whether the repeated-bout protective effect after eccentric exercise depends on inflammation and oxidative stress

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, placebo-controlled, parallel-group trial at the University of Bath enrolling healthy adults who perform a 20-minute bench-stepping eccentric exercise. Participants will receive either acute vitamin C and ibuprofen or placebo before/after the exercise, and researchers will measure soreness, performance on a later bout, blood markers of inflammation, and markers of oxidative stress. The study compares the size of the initial exercise-induced damage and the magnitude of the repeated-bout effect between groups to see if antioxidant/anti-inflammatory treatment alters the protective adaptation. Eligibility is limited to adults 18–45 with BMI 18.5–29.9 who are able to complete the exercise and are not taking anti-inflammatory medications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 - 45 years of age
* BMI 18.5 - 29.9 kg/m2
* Able to perform 20-minutes of bench stepping exercise
* Capable and willing to provide consent (oral and written)

Exclusion Criteria:

* Familiarised with bench stepping exercise procedures
* Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
* Participants exhibiting any alteration in clinical inflammation parameters due to other cause
* Participants currently being prescribed any anti-inflammatory medications

Where it's running

• University of Bath
  Bath, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.