Whether the repeated-bout protective effect after eccentric exercise depends on inflammation and oxidative stress
Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?
NA · University of Bath · NCT07472244
This project will test if taking vitamin C and ibuprofen around a hard eccentric workout changes the protective repeated-bout effect in healthy adults aged 18–45.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 52 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Bath (other) |
| Locations | 1 site (Bath) |
| Trial ID | NCT07472244 on ClinicalTrials.gov |
What this trial studies
This is a double-blind, placebo-controlled, parallel-group trial at the University of Bath enrolling healthy adults who perform a 20-minute bench-stepping eccentric exercise. Participants will receive either acute vitamin C and ibuprofen or placebo before/after the exercise, and researchers will measure soreness, performance on a later bout, blood markers of inflammation, and markers of oxidative stress. The study compares the size of the initial exercise-induced damage and the magnitude of the repeated-bout effect between groups to see if antioxidant/anti-inflammatory treatment alters the protective adaptation. Eligibility is limited to adults 18–45 with BMI 18.5–29.9 who are able to complete the exercise and are not taking anti-inflammatory medications.
Who should consider this trial
Good fit: Ideal candidates are healthy adults 18–45 years old with BMI 18.5–29.9 who can complete 20 minutes of bench-stepping, are not familiarised with that exercise protocol, and are not taking anti-inflammatory medications.
Not a fit: People older than 45, with BMI outside 18.5–29.9, with ongoing clinical inflammation from other causes, using prescribed anti-inflammatory drugs, or unable to perform the exercise are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the results could guide athletes on whether common supplements like vitamin C and ibuprofen help or hinder protective adaptations after strenuous eccentric exercise.
How similar studies have performed: Previous research reliably shows a repeated-bout effect and that antioxidants or NSAIDs can modify inflammatory and oxidative responses, but randomized trials directly testing whether such supplements reduce the repeated-bout protective adaptation are limited and have mixed results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 - 45 years of age * BMI 18.5 - 29.9 kg/m2 * Able to perform 20-minutes of bench stepping exercise * Capable and willing to provide consent (oral and written) Exclusion Criteria: * Familiarised with bench stepping exercise procedures * Not cleared for exercise by health questionnaires or physical activity readiness questionnaire * Participants exhibiting any alteration in clinical inflammation parameters due to other cause * Participants currently being prescribed any anti-inflammatory medications
Where this trial is running
Bath
- University of Bath — Bath, United Kingdom (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Exercise Recovery