What factors affect pregnancy success after IUI
Factors Associated With Clinical Pregnancy Outcomes in Intrauterine Insemination (IUI) Cycles
This project will try to see if hormone levels on trigger day, follicle and uterine measurements, and sperm quality are linked to the chance of a clinical pregnancy after IUI for couples who had IUI cycles.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years to 42 Years |
| Sex | Female |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT07344623 on ClinicalTrials.gov |
What this trial studies
This is a retrospective analysis of approximately 3,000 intrauterine insemination (IUI) cycles performed at the Chinese University of Hong Kong using existing clinical records. The study examines hormone measurements (LH, estradiol, progesterone) on trigger day, follicular response, endometrial thickness, and sperm parameters as predictors of clinical pregnancy (gestational sac with fetal heartbeat). Statistical methods include univariate and multivariate logistic regression, mediation and interaction analyses, ROC/AUC performance, and machine-learning model development with internal validation. The protocol also compares natural versus gonadotropin-stimulated IUI cycles and examines incremental cost per clinical pregnancy.
Who should consider this trial
Good fit: Ideal candidates are couples who underwent at least one IUI cycle using their own sperm and have complete clinical and laboratory records available at the center.
Not a fit: Patients who used donor sperm, who lack core outcome data, or whose infertility is managed primarily by IVF rather than IUI are unlikely to benefit from the study's findings.
Why it matters
Potential benefit: If successful, the results could help predict which couples are most likely to achieve a clinical pregnancy after IUI and guide more personalized, cost-conscious treatment choices.
How similar studies have performed: Previous observational studies have identified links between hormones, endometrial factors, sperm quality and IUI outcomes, but comprehensive predictive models with machine learning and formal cost-effectiveness comparisons are relatively uncommon.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Couples who underwent at least one IUI-intrauterine insemination cycle. Exclusion Criteria: * Couples who used donor sperm. * Cases with missing core outcome data
Where this trial is running
Hong Kong
- The Chinese University of Hong Kong — Hong Kong, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.