Westlake frequent-sampling gut microbiome cohort
Westlake Frequent-sampling Cohort
Westlake University · NCT07460687
This 15-day test asks healthy adults to collect daily stool and saliva samples, save samples of their meals, and wear a continuous glucose monitor to see how stable the gut microbiome is day-to-day and how it relates to food and blood sugar.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Westlake University (other) |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT07460687 on ClinicalTrials.gov |
What this trial studies
This non-interventional observational project enrolls healthy adults for a 15-day period of high-frequency sampling under free-living conditions. Participants collect daily saliva (5 mL) and stool (≈40 g) samples and provide samples of every meal for DNA sequencing, while wearing a continuous glucose monitor to continuously record blood glucose. The combined microbial, dietary, and glycemic datasets are used to map temporal community structure, identify core microbiota stability, and distinguish intra-individual fluctuations from inter-individual differences. Study conduct is overseen by a Data and Safety Monitoring Board and approved by the Westlake University Ethics Committee.
Who should consider this trial
Good fit: Ideal participants are healthy adults living in Hangzhou who can give informed consent, provide daily stool, saliva, and meal samples for 15 days, and wear a continuous glucose monitor.
Not a fit: People with chronic gastrointestinal or metabolic diseases, major organ disease, certain psychiatric disorders, pregnancy or lactation, heavy smoking or substance addiction, or those taking relevant daily medications are excluded and unlikely to receive benefit from this study.
Why it matters
Potential benefit: If successful, the results could clarify normal day-to-day microbiome variability and inform personalized nutrition or timing of interventions to support metabolic health.
How similar studies have performed: Prior lower-frequency microbiome studies have linked diet and microbiome composition, but combining daily high-frequency sampling with continuous glucose monitoring is relatively novel and aims to address gaps from earlier work.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants reside in Hangzhou Exclusion Criteria: * Refusing or unable to give informed consent * Participants with chronic gastrointestinal diseases and take daily relevant medications * Participants with metabolic diseases including diabetes, hypertension and cardiovascular diseases (CVD) * Participants with craniocerebral trauma, cancer, liver disease, kidney disease, or other critical illness, or history of operation or medication * Participants with bulimia nervosa, post-traumatic stress disorder (PTSD), chronic anxiety and depression or other critical neuronal disorder or history of relevant medication * Being or to be pregnant or lactating. * Participants with history of alcohol or drug addiction, or smoke above 15 cigarettes per day * Concurrently participating other clinical trials.
Where this trial is running
Hangzhou, Zhejiang
- Westlake University — Hangzhou, Zhejiang, China (RECRUITING)
Study contacts
- Principal investigator: Ju-Sheng Zheng, PhD — Westlake University
- Study coordinator: Ju-Sheng Zheng, PhD
- Email: zhengjusheng@westlake.edu.cn
- Phone: 86-0571-86915303
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Health Adults, Stability of Microbiome, Microbiome