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Clinical trial Recruiting at 2 sites Interventional Ages 20 to 70

Weight loss program for overweight patients with type 2 diabetes

Official title: eHealth Diabetes Remission Trial (Swedish: Remission av Typ 2 Diabetes Med hjälp av eHälsa

Run by Umeå University · NCT05491005 · Data updated 2026-11-12

This study is testing a weight loss program for overweight people with type 2 diabetes to see if a strict diet and different types of support can help them lose weight and possibly improve their diabetes over two years.

Quick facts

Study typeInterventional
Ages20 Years to 70 Years
SexAll
Enrollment106 (estimated)
SponsorUmeå University
Academic / other
Locations3 sites (Jönköping and 2 other locations)
StatusRecruiting
StartedAugust 31, 2022
Main results expectedJanuary 31, 2028
Study endsJanuary 31, 2028
Registry record updatedApril 30, 2026
Trial IDNCT05491005 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are overweight individuals with type 2 diabetes diagnosed within the last six years and a BMI of 27 kg/m2 or higher.

Probably not a fit

Patients currently on insulin treatment or with severe health conditions such as recent myocardial infarction or severe heart failure may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial involves overweight patients with type 2 diabetes who undergo a total diet replacement of 850 kcal/day for three months, aiming for a weight loss of 15 kg and potential diabetes remission. Participants are randomized into two groups: one receiving eHealth follow-up and the other receiving face-to-face follow-up, although both groups receive the same dietary advice. After the initial three months, food is gradually reintroduced, and a tailored energy prescription is provided to prevent weight regain. The total duration of the study is two years, with ongoing support through cognitive behavioral therapy to help maintain weight loss.

Why it matters

Potential benefit: If successful, this program could lead to significant weight loss and remission of type 2 diabetes for participants.

How similar studies have gone: Other studies have shown promising results with similar dietary interventions for diabetes remission, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Type 2 diabetes with duration 0-6 years
* BMI 27 kg/m2 and higher
* HbA1c 43 mmol/mol or higher (48 or higher if without diabetes medication)

Exclusion Criteria:

* Insulin treatment
* Weight loss more than 5 kg during the past 6 months
* Diagnosed eating disorder
* eGFR \< 30 ml/min/1,73m2
* Myocardial infarction last six months
* Severe heart failure (NYHA class III)
* Ongoing cancer
* Pregnancy
* Treatment with antipsychotic drugs

Where it's running

  • Bra Liv Råslätt vårdcentral
    Jönköping, Sweden     Recruiting
  • Department of Public Health and Clinical Medicine, Medicine
    Umeå, Sweden     Recruiting
  • Örnsköldsvik hospital
    Örnsköldsvik, Sweden     Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Diabetes Mellitus, Type 2 185Umeå University 36
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.