Weight-loss diets based on gut microbiome analysis
The Efficacy of Weight-loss Diet Decision-making Based on Initial Gut Metabolic Modules (GMMs)
This study is testing if personalized weight-loss diets based on your gut bacteria can help you lose weight better than standard diets.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 20 Years to 64 Years |
| Sex | All |
| Sponsor | Taipei Veterans General Hospital, Taiwan Government |
| Locations | 1 site (Taipei, Beitou District) |
| Trial ID | NCT06373887 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of weight-loss diets tailored to individuals' gut microbiome profiles. Participants will be assigned to either a low-carbohydrate diet rich in monounsaturated fatty acids or a low-fat diet with whole grains, both designed to have the same caloric content. The research aims to understand how variations in gut microbiota influence weight loss outcomes, particularly focusing on the metabolic pathways linked to microbial functions. By analyzing gut metabolic modules, the study seeks to identify which dietary approach yields better results for weight loss based on individual microbiome characteristics.
Who should consider this trial
Good fit: Ideal candidates are overweight or obese individuals with a BMI of 24 or higher who do not have chronic diseases or are on medication.
Not a fit: Patients with a history of significant weight change, chronic diseases, or those on specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective weight-loss strategies for individuals based on their gut microbiome.
How similar studies have performed: Previous studies have indicated that personalized dietary interventions based on gut microbiome analysis can lead to improved weight loss outcomes, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with BMI \>=24 overweight and obesity without chronic disease or medication use. Exclusion Criteria: * a) Medication history of diabetes, hypertension, dyslipidemia, and cardiovascular diseases within two months. b) Bodyweight change within three months before the study. (+4kg). c) Participate in weight loss programs in the preceding 12 months. d) Use ABX, PPI, NSAID, laxatives, oral contraceptives, and antipsychotics within two months. e) Previous operations history for managing obesity (bariatric procedures and gastric bypass operation). f) Current smoking: at least 20 monthly cigarettes for over half a year. g) Alcohol consumption (\> two glasses per day). h) Pregnancy, breastfeeding, chronic kidney dis-ease, autoimmune, viral chronic diseases (hepatitis C, B, HIV, etc.), and neoplastic diseases. i) Consumption of vegetarian or unusual diets. The Institutional Review Board approved all study protocols at TVGH.
Where this trial is running
Taipei, Beitou District
- Taipei Veterans General Hospital — Taipei, Beitou District, Taiwan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.