Web intervention for parents of children with genetic syndromes

Promoting Prosocial Behavior in Syndromic Intellectual and Developmental Disabilities

Not applicable Interventional Rush University Medical Center · NCT06139172

This study is testing a new online therapy program to help parents of young children with genetic syndromes learn better ways to manage their kids' challenging behaviors.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment92 (estimated)
Ages2 Years to 12 Years
SexAll
SponsorRush University Medical Center Academic / other
Locations1 site (Chicago, Illinois)
Trial IDNCT06139172 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of a telehealth functional behavioral therapy designed to enhance communication and behavioral strategies for children with syndromic intellectual and developmental disorders. Participants, aged 2-12 years, will undergo virtual assessments and receive weekly or biweekly coaching sessions with a therapist over a period of 3-6 months. The intervention focuses on parent-implemented strategies to address disruptive behaviors associated with various genetic syndromes.

Who should consider this trial

Good fit: Ideal candidates are children aged 2-12 years with a diagnosed genetic syndrome and documented developmental delays or intellectual disabilities.

Not a fit: Patients with high levels of aggression or those requiring more intensive care than what can be provided remotely may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve communication and behavioral outcomes for children with genetic syndromes and their families.

How similar studies have performed: Other studies have shown promise in using telehealth interventions for behavioral therapy, indicating potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age(s) 2-12 years old at time of enrollment
* Existing genetic syndrome based on clinical or genetic diagnosis and confirmed by medical records
* Documented diagnosis of global developmental delay (GDD) or intellectual disability (ID)
* estimated ID in all ranges
* Disruptive behavior challenges determined to be clinically appropriate for remote, parent-implemented coaching based on clinician determination of acuity of problem behaviors
* Caregiver who is able to consent in English.
* Parent/caregiver available for weekly intervention sessions
* Stable psychosocial and psychiatric treatments 3 months prior to baseline visit.

Exclusion Criteria:

* High levels of aggression that mitigate remote or outpatient treatment as defined by clinician judgement and/or ABC Irritability scores above 20 (i.e., higher level of care needed than provided by study procedures)
* Medical or psychiatric instability that may limit study participation
* Meaningful change in medication or psychosocial interventions 3 months prior to baseline visit
* Limitations in technology access that may hinder participation in remote trial (e.g., declining support provided by study participation)

Where this trial is running

Chicago, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Telomeric 22Q13 Monosomy SyndromeTuberous SclerosisHamartoma Syndrome, MultipleFragile X SyndromeAngelman SyndromeRett SyndromeChromosome 15Q, Partial DeletionCreatine Deficiency, X-linked
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.