VNS Dosing Protocol: Faster Seizure Control for Epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two VNS programming paradigms in adults with epilepsy: a modified rapid titration approach called the Augusta Way and the standard titration used in routine care. Participants will have up to three visits every three months over two years, complete quality-of-life and cognitive questionnaires, and keep a seizure diary. The study aims to determine if the Augusta Way reduces seizure frequency more quickly while monitoring safety and tolerability. Results will inform clinicians about a potentially updated reference model for VNS parameter escalation in drug-resistant epilepsy. Enrollment is limited to adults eligible for VNS implantation at Augusta University and Wellstar MCG Hospital, with informed consent obtained.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects who are clinically determined to be candidates for VNS implantation for seizure control
* Subject/legally authorized representative able to provide informed consent.

Exclusion Criteria:

* Subjects with VNS system treating pathologies other than drug refractory epilepsy or medical co-morbidities that prevent any surgical intervention

Where it's running

• Wellstar MCG Hospital
  Augusta, Georgia, United States Recruiting

Study contacts

• Study coordinator: Brandy Quarles, MPH
• Email: bquarles@augusta.edu
• Phone: 706-721-0390

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.