Vitreous zonule and its role in primary angle-closure glaucoma.
Official title: A Cross-Sectional, Prospective Observational Study on the Role of the Vitreous Zonule in the Pathogenesis of Primary Angle-Closure Glaucoma
Run by Peking University People's Hospital · NCT07523139 · Data updated 2026-11-12
This project will try 3D ultrasound imaging to see if the vitreous zonule contributes to angle-closure glaucoma in adults with or at risk for primary angle-closure disease and in healthy people.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 30 Years to 79 Years |
| Sex | All |
| Enrollment | 440 (estimated) |
| Sponsor | Peking University People's Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07523139 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 30–80 with a diagnosis of PACS, PAC, or PACG, or healthy controls with open angles, lens opacity below grade 2 (LOCS III), and ability to give informed consent are eligible.
✕Probably not a fit
Patients with prior intraocular surgery or laser, other significant anterior or posterior segment eye diseases, or systemic conditions that affect ocular measurements, as well as those outside the 30–80 age range, are unlikely to benefit from this observational imaging study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will enroll adults with primary angle-closure disease (PACS, PAC, PACG) and age-matched healthy controls to undergo detailed eye exams, gonioscopy, biometry with IOLMaster, and ultrasound biomicroscopy (UBM). Investigators will analyze vitreous zonule (VZ) morphology, location, visible quadrants, and anterior segment parameters across age and axial-length groups and compare findings between healthy eyes and PACD eyes. The team will also develop and validate a rotational-scanning three-dimensional UBM (3D-UBM) method to reconstruct the circumferential VZ. No therapeutic interventions are given; the focus is imaging, measurement, and method development.
Why it matters
Potential benefit: If successful, improved 3D imaging and understanding of the vitreous zonule could help identify patients at risk and guide more targeted diagnosis or management of angle-closure glaucoma.
How similar studies have gone: Prior work using standard UBM has suggested a role for the vitreous zonule in angle closure, but circumferential 3D reconstruction with rotational 3D-UBM is largely novel and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Age between 30 and 80 years, inclusive. 2. Diagnosis of primary angle-closure disease (PACS, PAC, or PACG) according to standardized gonioscopic criteria; or healthy controls with open angles. 3. Lens opacity graded \< 2 for cortical and nuclear opacities according to the Lens Opacities Classification System III (LOCS III). 4. Ability and willingness to provide written informed consent. Exclusion Criteria: 1\. Any intraocular disease affecting the anterior or posterior segment, including but not limited to corneal disease, iris abnormalities, lens disorders other than age-related cataract, vitreous disorders, uveoretinal diseases, or optic neuropathies. 2. Prior intraocular surgery or laser treatment, including cataract surgery, trabeculectomy, laser trabeculoplasty, laser peripheral iridotomy, laser iridoplasty, or vitreoretinal surgery. 3. Systemic diseases that may affect ocular examination or confound measurements, such as end-stage cardiac disease, renal disease, pulmonary disease, or advanced malignancy. 4. Inability to undergo ultrasound biomicroscopy (UBM) examination due to inability to maintain supine position or other contraindications. 5. Pregnancy or lactation. 6. Any condition that, in the opinion of the investigator, would compromise the participant's ability to comply with study procedures or affect the validity of the study results.
Where it's running
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Peking University People's Hospital
Beijing, China Recruiting
Study contacts
- Study coordinator: Kun Lv, M.D.
- Email: lvkun0327@163.com
- Phone: 13681213130
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Phacoemulsification with goniosynechialysis versus trabeculectomy for primary angle-closure glaucoma
This trial will see if phacoemulsification plus goniosynechialysis controls eye pressure and causes fewer complications than trabeculectomy in adults with primary angle-closure glaucoma.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.