Vitamin D3 for heart rate variability in men with Parkinson's and low vitamin D

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Male Parkinson's patients aged 51–70 with vitamin D deficiency or insufficiency and mild-to-moderate disease (Hoehn and Yahr I–III) will undergo baseline heart rate variability (HRV) testing, then receive 50,000 IU vitamin D3 once weekly for eight weeks, followed by repeat HRV testing. This is a self-controlled pre–post interventional design comparing each participant's HRV before and after supplementation. Participants must be on levodopa, meet BMI criteria (18.5–24.9 kg/m2), and not have severe cardiovascular, renal, hepatic, respiratory, endocrine, or neurological comorbidities or take excluded medications. The primary outcome is change in HRV parameters as markers of cardiac autonomic balance.

Why it matters

Who can join: the full rules

IInclusion criteria:

* Male patients with of Parkinson's disease diagnosed by neurologist with unilateral or bilateral involvement and mild to moderate disability according to Hoehn and Yahr (H-Y) scale (I-III)
* Age: 51-70 years
* BMI: 18.5-24.9 kg/m2
* Vitamin D3 deficient or insufficient
* On Levodopa medication

Exclusion criteria:

1. Patients with a history of drug abuse including alcoholism.
2. Patients on following drugs will be excluded-

   * Antioxidant vitamin supplements
   * Lipid lowering medications
   * Antihypertensive drug
   * Anti-arrhythmic drug
   * Sedatives
3. All patients with the history of or clinical manifestation of currently suffering from following diseases \& condition will be excluded

   * Severe Cardiovascular disorders
   * Severe neurological disorders
   * Severe Respiratory disorders
   * Severe Renal insufficiency (S. Creatinine \> 1.5 mg/dl, Acute or chronic kidney disease)
   * Severe Endocrine disease
   * Severe Arthritis
   * Severe Liver diseases
   * Severe Neoplastic disease
   * Severe Psychiatric disorder
   * Current use of iron, zinc, calcium, magnesium and multivitamin supplementation
   * Already performing yoga or breathing exercise
   * Hypercalcemia

Where it's running

• Bangladesh Medical University
  Dhaka, Shahbag, Bangladesh Recruiting

Study contacts

• Study coordinator: Registrar BMU
• Email: registrar@bsmmu.edu.bd
• Phone: +880255165708

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.