Vitamin D levels and spinal anesthesia-related low blood pressure during elective C-section
Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section
Duzce University · NCT07057362
This study will test whether low vitamin D makes low blood pressure from spinal anesthesia more likely or more severe in pregnant women having an elective C-section.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Duzce University (other) |
| Locations | 1 site (Düzce, Merkez) |
| Trial ID | NCT07057362 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study enrolling pregnant women scheduled for elective cesarean delivery under spinal anesthesia. Participants will have serum 25-hydroxyvitamin D measured before surgery and continuous intraoperative hemodynamic monitoring during the procedure. Episodes of hypotension (≥20% drop in systolic blood pressure or <90 mmHg) and their severity will be recorded and analyzed by vitamin D status. Standard perioperative management including fluid preload and vasopressors will be used per routine care.
Who should consider this trial
Good fit: Pregnant women aged 18 or older scheduled for elective cesarean delivery under spinal anesthesia who can provide informed consent and are not taking recent vitamin D supplements are ideal candidates.
Not a fit: Patients having emergency C-sections, those with significant cardiovascular or autonomic disorders, or those already using vitamin D supplements are unlikely to benefit from this study's findings.
Why it matters
Potential benefit: If low vitamin D is linked to worse spinal anesthesia hypotension, preoperative screening and targeted management could reduce maternal and fetal complications during C-section.
How similar studies have performed: Previous observational work has suggested links between vitamin D deficiency and altered vascular or autonomic function, but few studies have specifically examined spinal anesthesia-induced hypotension, so this approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women aged 18 years or older * Scheduled for elective cesarean delivery under spinal anesthesia * Able and willing to provide written informed consent Exclusion Criteria: * Emergency cesarean sections * History of significant cardiovascular disease (e.g., arrhythmia, heart failure) * Known neurological disorders affecting autonomic function * Current vitamin D supplementation within the past 30 days * Inability to undergo blood sampling or provide valid hemodynamic data * Contraindication to spinal anesthesia
Where this trial is running
Düzce, Merkez
- Duzce University Faculty of Medicine, Department of Anesthesiology and Reanimation — Düzce, Merkez, Turkey (Türkiye) (RECRUITING)
Study contacts
- Study coordinator: Gizem DEMIR SENOGLU
- Email: gizem123demir@hotmail.com
- Phone: +905059313588
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Spinal Anesthesia-induced Hypotension, Vitamin D Deficiency, Cesarean Section