Vitamin C's effect on gingival pigment recurrence after removal
Official title: Patient Response and Recurrence Rate Following Adjunctive Intra-Mucosal or Topical Ascorbic Acid To Gingival Depigmentation Using Surgical Scalpel Technique: (Randomized Clinical and Histological Trial)
Run by Ain Shams University · NCT06312605 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if giving vitamin C through injections or applying it on the skin can help prevent the return of gum discoloration after it's been removed in healthy patients who care about their appearance.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06312605 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy individuals aged 18-40 with physiological gingival melanin pigmentation and a thick gingival phenotype.
✕Probably not a fit
Patients who are pregnant, lactating, smokers, or have conditions that may affect vitamin C metabolism or cause gingival depigmentation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the impact of vitamin C on the recurrence of gingival pigmentation following surgical removal in healthy patients concerned about aesthetics. Participants will be divided into two groups: one receiving injectable vitamin C and the other applying it topically, with follow-up visits to assess pigment recurrence and patient satisfaction over one year. The study aims to compare the histological responses of the tissues in both groups to determine the most effective method of vitamin C administration.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for preventing gingival pigment recurrence, enhancing patient satisfaction with aesthetic outcomes.
How similar studies have gone: Previous studies have shown promising results for vitamin C in treating gingival pigmentation, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Both genders aged from 18-40. Systemically free patients from any disease as evidenced by the health questionnaire, using modified Cornell medical index and classified as ASA class I. Patients who were diagnosed to have physiological gingival melanin pigmentation on the maxillary or mandibular keratinized gingiva with Dummett oral pigmentation score 2 or more. Patients with thick gingival phenotype ≥ 1.5 mm. Exclusion criteria: Pregnant or lactating females Smokers (water pipe, cigar or cigarette smoking). Patients taking or have taken any drug that may cause gingival depigmentation as chloroquine, minocycline, zidovudine, chlorpromazine, ketoconazole and bleomycin . Any cause for supplemental intake of vitamin C. Reported allergy to ascorbic acid or to any of its derivatives as reported in health questionnaire . Clinically diagnosed periodontitis regarding the following criteria probing depth \>3mm, clinical attachment loss ≥ 1mm and bleeding on probing \> 10% . Patients with poor oral hygiene, incompliant to treatment and persistence gingival inflammation after phase I periodontal therapy.
Where it's running
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Faculty AinShams University
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: Hala K. Abd-El-Gaber, Professor — Professor of Oral Medicine, Oral Diagnosis and Periodontology Faculty of Dentistry - Ain Shams University
- Study coordinator: Eman O. Hashem, MSc
- Email: emanemmy123456@gmail.com
- Phone: 01025743781
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Gingival Depigmentation with Vitamin C and Glutathione vs. Surgical Depigmentation
This study tests whether vitamin C with glutathione injections can depigment pigmented gums as effectively as surgical depigmentation in adults.
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Microneedling with topical silymarin versus diode laser and scalpel for gingival pigmentation
We will test whether microneedling plus topical silymarin, diode laser, or scalpel works better to improve the appearance of gums in people with gingival hyperpigmentation.
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Microneedling with platelet-rich plasma versus microneedling alone for reducing gum (gingival) pigmentation
This test sees if adding platelet-rich plasma (PRP) to microneedling lightens gum pigmentation more than microneedling alone in adults with gingival melanin hyperpigmentation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.