Vitamin C to prevent urinary tract infections after gynecological surgeries
Vitamin C for the Prevention of Catheter-associated Urinary Tract Infections in Women Who Undergo Elective Gynecological Surgeries: a Randomized Double-blinded Controlled Trial
This study is testing if taking Vitamin C can help women who have gynecological surgeries avoid urinary tract infections caused by catheters.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | Female |
| Sponsor | American University of Beirut Medical Center Academic / other |
| Locations | 1 site (Moscow) |
| Trial ID | NCT05913180 on ClinicalTrials.gov |
What this trial studies
This is a double-blind, placebo-controlled randomized trial designed to evaluate the effectiveness of Vitamin C supplementation in preventing catheter-associated urinary tract infections (CAUTIs) in women undergoing elective gynecological surgeries. The study targets women who are at a higher risk for UTIs due to the nature of these surgeries and the use of catheters. Participants will receive either 1000 mg of Ascorbic Acid or a placebo, and the incidence of UTIs will be monitored post-surgery. The goal is to determine if Vitamin C can significantly reduce the occurrence of UTIs in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates for this study are nonpregnant women aged 18 and older who are scheduled for elective gynecological surgery.
Not a fit: Patients who may not benefit from this study include those with existing urinary tract infections, certain medical conditions like diabetes or renal disorders, or those already taking Vitamin C supplements.
Why it matters
Potential benefit: If successful, this study could provide a simple and cost-effective method to reduce the incidence of urinary tract infections in women after gynecological surgeries.
How similar studies have performed: While there is limited strong clinical evidence supporting the use of Vitamin C for UTI prevention, this approach has been suggested in other contexts, making this study a novel exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nonpregnant women * 18 years of age or older * Undergoing elective GYN surgery Exclusion Criteria: * Pregnant women * Already taking Vitamin C supplementation * Nephrolithiasis * Congenital anomaly or neurogenic bladder * Allergy to ascorbic acid * On therapeutic anticoagulant medicine during the 6 weeks after surgery * Gynecological surgery involving fistula repair or a vaginal mesh removal * Positive Urinalysis in the pre-admission unit * Recurrent UTIs * Diabetes * G6PD * Hemochromatosis * Renal disorders
Where this trial is running
Moscow
- Moscow State University of Medicine and Dentistry — Moscow, Russia (Recruiting)
Study contacts
- Principal investigator: Tony Bazi, M.D. — American University of Beirut Medical Center
- Study coordinator: Tony Bazi, M.D.
- Email: tb04@aub.edu.lb
- Phone: 9611350000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.