Vitamin B12, folic acid, and vitamin D levels in women of childbearing age in Herzegovina
Assessment of Serum Concentrations of Vitamin B12, Folic Acid, and Vitamin D in Women of Reproductive Age to Determine Recommended Supplementation Doses in the Preconception Period and During Pregnancy
This project will test blood levels of vitamin B12, folic acid, and vitamin D in women aged 18–49 in Herzegovina to see if current supplement advice matches their needs.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 360 (estimated) |
| Ages | 18 Years to 49 Years |
| Sex | Female |
| Sponsor | University of Mostar Academic / other |
| Locations | 1 site (Mostar) |
| Trial ID | NCT07100795 on ClinicalTrials.gov |
What this trial studies
This cross-sectional observational project will enroll 360 women aged 18–49 in Herzegovina between December 2024 and December 2025 and collect blood samples after informed consent. Serum concentrations of vitamin B12, folic acid, and vitamin D will be measured using chemiluminescent microparticle immunoassays (CMIA) on the Abbott Alinity ci platform. Women with diabetes, epilepsy, oncological disease, inflammatory bowel disease, or recent supplementation will be excluded to focus on baseline population status. Results will estimate the prevalence of deficiency, adequacy, or excess and inform locally adapted preconception and pregnancy supplementation recommendations.
Who should consider this trial
Good fit: Women aged 18–49 who live in Herzegovina, are not currently taking vitamin B12, folic acid, or vitamin D supplements, and can attend visits at Mostar study sites are ideal candidates.
Not a fit: Women with excluded conditions (diabetes, epilepsy, cancer, inflammatory bowel disease) or who have taken the specified supplements in the past three months are unlikely to benefit from participating or from immediate guideline changes.
Why it matters
Potential benefit: If successful, the results could lead to locally tailored supplement recommendations that better prevent deficiency or excess during preconception and pregnancy.
How similar studies have performed: Similar regional cross-sectional surveys have successfully identified local micronutrient gaps and informed public health recommendations, so the approach is established though this population has not been characterized previously.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women of reproductive age (18-49 years) * Informed consent obtained Exclusion Criteria: * diabetes (Type I or II) * epilepsy * oncological diseases, inflammatory bowel disease * supplementation with vitamin B12, folic acid, or vitamin D within the last 3 months
Where this trial is running
Mostar
- University Clinical Hospital Mostar, Primary Health Care Center Mostar — Mostar, Bosnia and Herzegovina (Recruiting)
Study contacts
- Study coordinator: Vajdana Tomić, Professor, MD, PhD
- Email: vajdana.tomic@mef.sum.ba
- Phone: 0038763790012
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.