Vision after Clareon PanOptix versus another multifocal intraocular lens
Official title: Visual Performance Differences Between Clareon PanOptix and a Comparable Multifocal Intraocular Lens
Run by Argus Research Center, Inc. · NCT07006428 · Data updated 2026-11-12
This study will test whether people having cataract surgery have better vision and satisfaction with the Clareon PanOptix lens compared with another multifocal lens.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 290 (estimated) |
| Sponsor | Argus Research Center, Inc. Academic / other |
| Locations | 3 sites (Torrance, California and 2 other locations) |
| Status | Recruiting |
| Started | May 7, 2025 |
| Main results expected | October 2025 |
| Study ends | November 2025 |
| Registry record updated | June 5, 2025 |
| Trial ID | NCT07006428 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with bilateral age-related cataracts who either already have bilateral Clareon PanOptix or comparable multifocal IOLs implanted (for the pilot phase) or are planning bilateral femtosecond laser-assisted cataract surgery with bilateral Clareon PanOptix or comparable multifocal IOL implantation (for the comparison phase).
✕Probably not a fit
Patients with significant ocular comorbidities, poor preoperative visual potential, unilateral cataract, or who are not targeted for emmetropia are unlikely to experience benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This two-part, multicenter, investigator-initiated study compares visual outcomes and patient satisfaction after bilateral implantation of the Clareon PanOptix (or PanOptix Toric) versus a comparable multifocal intraocular lens. The first pilot phase includes retrospective and prospective data from patients 2.5–5 months after implantation, while the second phase is a prospective, randomized comparison of planned bilateral femtosecond laser-assisted cataract surgery with bilateral IOL implantation. Key outcomes include distance, intermediate and near visual acuity and patient-reported satisfaction. The study is conducted at three community ophthalmology sites in the United States.
Why it matters
Potential benefit: If successful, the study could identify which multifocal IOL provides better overall vision and higher patient satisfaction after cataract surgery.
How similar studies have gone: Previous studies comparing multifocal intraocular lenses, including published results for PanOptix, have shown improvements in range of vision and patient satisfaction, so this approach has precedent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Stage 1: IIT Pilot * Willing and able to understand and sign informed consent. * Adult patients previously diagnosed with age-related cataracts bilaterally. * Previous bilateral age-related cataract removal and with bilateral implantation of the Clareon PanOptix/ Clareon PanOptix Toric (T3-T4) or Comparable Multifocal Intraocular Lens (equivalent to T3-T4) closest to 2.5-5-months after implantation and \>2 weeks post YAG (if done) that were targeted for emmetropia. * Best monocular corrected distance visual acuity was expected to be 0.1 logMAR (Snellen 20/25) or better in both eyes pre-operatively as determined by surgeon. * Normal ocular findings aside from cataract. Stage 2: Comparison * Willing and able to understand and sign informed consent. * Adult patient diagnosed with age-related cataracts bilaterally. * Planned bilateral cataract removal by femtosecond laser-assisted phacoemulsification with bilateral implantation of the Clareon PanOptix/Clareon PanOptix Toric (T3-T4) or Comparable Multifocal Intraocular Lens (equivalent to T3-T4). * Best monocular corrected distance visual acuity expected to be 0.1 logMAR (Snellen 20/25) or better in both eyes postoperatively as determined by surgeon. * Residual astigmatism expected to be ≤ 0.50 diopters in both eyes postoperatively as determined by surgeon (after using either toric IOL or arcuate incision with laser). * Normal ocular findings aside from cataract. Exclusion Criteria: Stage 1: IIT Pilot * Corneal pathology, irregular astigmatism, preexisting macular disease and other retinal degenerative diseases, diabetic retinopathy that is expected to cause future vision loss, glaucoma, severe dry eye disease, nystagmus, strabismus, zonular laxity or dehiscence, pseudoexfoliation. * Previous history of any ocular surgery including corneal refractive surgery. * Participation in another clinical study that could interfere with the results. * Patients with monovision correction. * Any active ocular infection or inflammation. Stage 2: Comparison * Corneal pathology, irregular astigmatism, preexisting macular disease and other retinal degenerative * diseases that is expected to cause future vision loss, glaucoma, severe dry eye disease, nystagmus, strabismus, zonular laxity or dehiscence, pseudoexfoliation. * Previous history of any ocular surgery including corneal refractive surgery. * Participants desiring monovision. * History of amblyopia or monofixation syndrome with poor stereoscopic vision. * Total corneal HOA greater than 0.6um, coma less than 0.3um at 4mm-5mm scan depending on pre- op photopic topography. * Any planned simultaneous/combined procedures at time of cataract surgery (e.g. MIGs). * Participation in another clinical study that could interfere with the results. * Any active ocular infection or inflammation.
Where it's running
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Wolstan & Goldberg Eye Associates
Torrance, California, United States Recruiting -
Tyson Eye
Cape Coral, Florida, United States Recruiting -
North Georgia Eye Associates
Gainesville, Georgia, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.