Virtual-reality cooperative mirror therapy to improve arm movement after stroke
Official title: Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation
Run by National Cheng-Kung University Hospital · NCT07139379 · Data updated 2026-11-12
This trial will test whether a cooperative virtual-reality mirror therapy plus task-oriented training helps people with one-sided stroke improve arm function and brain activity more than standard virtual-reality mirror therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | National Cheng-Kung University Hospital Academic / other |
| Locations | 1 site (Tainan, Taiwan) |
| Status | Recruiting |
| Started | June 24, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | April 15, 2026 |
| Trial ID | NCT07139379 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are right-handed adults with a unilateral stroke at least six months ago who have preserved global cognition (MMSE >24) and no major visual or other brain disorders.
✕Probably not a fit
People with severe vision impairment, major cognitive-perceptual deficits, other brain diseases, bilateral strokes, or those within six months of stroke onset may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a novel Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy (VRMCTOMT) with conventional virtual-reality mirror therapy (VRMT), both combined with task-oriented training, in people with chronic unilateral stroke. Participants must be premorbidly right-handed, have relatively preserved cognition (MMSE >24), and have had their stroke more than six months earlier. The trial will measure changes in upper-extremity motor function and brain activity to determine which therapy yields greater improvements. Treatments are delivered in-person at National Cheng-Kung University Hospital using virtual-reality systems and repeated task-focused exercises.
Why it matters
Potential benefit: If successful, the cooperative bimanual VR approach could produce larger improvements in arm function and brain reorganization, helping patients perform daily tasks better.
How similar studies have gone: Previous studies of mirror therapy and virtual-reality rehabilitation have shown benefits for post-stroke arm function, but the specific generative bimanual cooperative VR technique is relatively new and less well tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of stroke with unilateral side involved; * A score of Mini-mental state examination greater than 24 for proving higher mental function * Time of onset \> 6 months before treatment begins; and * Premorbid right-handedness. Exclusion Criteria: * Severe vision impairment; * Major cognitive-perceptual deficit; * Other brain disease.
Where it's running
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National Cheng-Kung University Hospital
Tainan, Taiwan, Taiwan Recruiting
Study contacts
- Study coordinator: Hsiu-Yun Hsu, Ph.D
- Email: hyhsu@mail.ncku.edu.tw
- Phone: 886-6-2353535
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.