Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Virtual-reality cooperative mirror therapy to improve arm movement after stroke

Official title: Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation

Run by National Cheng-Kung University Hospital · NCT07139379 · Data updated 2026-11-12

This trial will test whether a cooperative virtual-reality mirror therapy plus task-oriented training helps people with one-sided stroke improve arm function and brain activity more than standard virtual-reality mirror therapy.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment44 (estimated)
SponsorNational Cheng-Kung University Hospital
Academic / other
Locations1 site (Tainan, Taiwan)
StatusRecruiting
StartedJune 24, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedApril 15, 2026
Trial IDNCT07139379 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are right-handed adults with a unilateral stroke at least six months ago who have preserved global cognition (MMSE >24) and no major visual or other brain disorders.

Probably not a fit

People with severe vision impairment, major cognitive-perceptual deficits, other brain diseases, bilateral strokes, or those within six months of stroke onset may not benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a novel Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy (VRMCTOMT) with conventional virtual-reality mirror therapy (VRMT), both combined with task-oriented training, in people with chronic unilateral stroke. Participants must be premorbidly right-handed, have relatively preserved cognition (MMSE >24), and have had their stroke more than six months earlier. The trial will measure changes in upper-extremity motor function and brain activity to determine which therapy yields greater improvements. Treatments are delivered in-person at National Cheng-Kung University Hospital using virtual-reality systems and repeated task-focused exercises.

Why it matters

Potential benefit: If successful, the cooperative bimanual VR approach could produce larger improvements in arm function and brain reorganization, helping patients perform daily tasks better.

How similar studies have gone: Previous studies of mirror therapy and virtual-reality rehabilitation have shown benefits for post-stroke arm function, but the specific generative bimanual cooperative VR technique is relatively new and less well tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinical diagnosis of stroke with unilateral side involved;
* A score of Mini-mental state examination greater than 24 for proving higher mental function
* Time of onset \> 6 months before treatment begins; and
* Premorbid right-handedness.

Exclusion Criteria:

* Severe vision impairment;
* Major cognitive-perceptual deficit;
* Other brain disease.

Where it's running

  • National Cheng-Kung University Hospital
    Tainan, Taiwan, Taiwan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.