Vinpocetine for people with Parkinson's on levodopa
Official title: Clinical Study to Evaluate Safety and Effectiveness of Vinpocetine in Patients With Parkinsonian Disease
Run by Tanta University · NCT07229664 · Data updated 2026-11-12
This trial will test whether adding vinpocetine to levodopa/carbidopa helps improve motor symptoms in people aged 50 and older with Parkinson's disease.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 50 Years to 70 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta) |
| Status | Recruiting |
| Started | November 10, 2025 |
| Main results expected | November 20, 2026 |
| Study ends | November 20, 2027 |
| Registry record updated | December 10, 2025 |
| Trial ID | NCT07229664 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 50 or older with a clinical diagnosis of Parkinson's disease who are currently taking levodopa/carbidopa and who do not have the listed exclusion conditions.
✕Probably not a fit
Patients with atypical or secondary parkinsonism, prior stereotaxic surgery, active malignancy, cardiovascular or coagulation disorders, current pregnancy or lactation, active substance addiction, use of anti-inflammatory drugs, or known allergy to the study drugs are unlikely to be eligible or to receive benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional Phase 2/3 trial enrolls patients aged 50 and older with Parkinson's disease who are already taking levodopa/carbidopa and gives vinpocetine as an add-on treatment compared with standard therapy. The protocol focuses on motor function and safety outcomes while excluding patients with atypical or secondary parkinsonism, prior stereotaxic surgery, cardiovascular disease, coagulation disorders, active malignancy, pregnancy or lactation, substance addiction, or known allergy to the study drugs. Patients taking anti-inflammatory drugs are also excluded to avoid confounding and bleeding risk. The trial is being conducted at Tanta University in Tanta, Egypt.
Why it matters
Potential benefit: If successful, adding vinpocetine to levodopa could modestly improve motor symptoms and daily functioning for people with Parkinson's disease.
How similar studies have gone: There is limited prior clinical trial evidence for vinpocetine in Parkinson's disease, so this approach is relatively novel and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age ≥ 50 years Both male and female will be included Negative pregnancy test and effective contraception. Diagnosed Parkinson's disease patient taking Levodopa Exclusion Criteria: Secondary causes of parkinsonism Patients taking anti-inflammatory drugs Atypical parkinsonian syndromes Prior stereotaxic surgery for Parkinson's disease Pregnancy and lactation Cardiovascular disease patients Patients with coagulation disorders Suffering from active malignancy Addiction to alcohol and / or drugs Known allergy to the studied medications
Where it's running
-
Tanta Unuversity
Tanta, Egypt Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.