Ventricular irrigation to treat ventriculitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Ventriculitis is a life-threatening infection of the brain’s ventricular system often associated with neurosurgical devices or procedures and with high mortality and long-term neurological disability. This interventional approach adds surgical ventricular irrigation—flushing and clearing pus from the ventricles, typically via external ventricular access—to standard antimicrobial therapy. The trial enrolls adults with purulent CSF (cloudy or yellow fluid with very high white blood cell counts), fever, and either positive CSF microbiology or CT/MRI evidence of intraventricular pus. Multiple hospitals in Anhui, China, led by RenJi Hospital and academic collaborators will track safety, infection clearance, mortality, and functional neurological outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65 years old;
* CSF is purulent (it appears cloudy or yellow) and white blood cell count over 1000×10\^6/L.
* Fever (\>38.0°C)
* Meet at least one of the following: 1. Patient has organism(s) identified from CSF by a culture or non-culture based microbiologic testing method; 2. Cranial CT or MRI indicating intraventricular floccule or pus.
* With consent form

Exclusion Criteria:

* With GCS score of 3
* With unstable vital signs such as no spontaneous breathing and blood pressure maintenance drugs
* With severe propensity for bleeding (Such as coagulation dysfunction, active bleeding, etc.), and unable to tolerate the surgical procedures or operations related to ventricular irrigation treatment.
* Pregnant or lactating women

Where it's running

• Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting
• Renji Hospital, School of Medicine, Shanghai Jiaotong University
  Shanghai, Shanghai Municipality, China Recruiting
• Shanghai Donglei Brain Hospital
  Shanghai, Shanghai Municipality, China Recruiting
• South taihu hospital affiliated to huzhou college
  Huzhou, Zhejiang, China Recruiting
• The First Affiliated Hospital of University of Science and Technology of China
  Hefei, Anhui, China Not yet recruiting
• The Second People's Hospital of Anhui Province
  Hefei, Anhui, China Not yet recruiting

Study contacts

• Principal investigator: Jiyao Jiang, Dr — Renji Hospital, School of Medicine, Shanghai Jiaotong University
• Study coordinator: Jiyao Jiang, Dr
• Email: jiyaojiang@126.com
• Phone: 021-68383729

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.