Vaspin gene changes and blood vaspin levels in people with psoriasis
Official title: Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris and Its Relation to Pathogenesis and Risk of the Disease
Run by Aswan University · NCT07320872 · Data updated 2026-11-12
This test will see if specific vaspin gene variants are linked to blood vaspin levels in people with psoriasis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Aswan University Academic / other |
| Drugs / interventions | methotrexate |
| Locations | 1 site (Aswān) |
| Status | Recruiting |
| Started | August 10, 2025 |
| Main results expected | August 10, 2026 |
| Study ends | August 20, 2026 |
| Registry record updated | January 6, 2026 |
| Trial ID | NCT07320872 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People of any age and gender with newly diagnosed psoriasis or who have been off psoriasis treatment for at least six months, who are not pregnant or breastfeeding and do not have chronic systemic or other inflammatory diseases, are ideal candidates.
✕Probably not a fit
Patients who are pregnant or lactating, have chronic cardiac, hepatic, or renal disease, malignancy, other inflammatory or autoimmune disorders, or who are currently on psoriasis treatment are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational, cross-sectional study at Aswan University Hospital will enroll patients with psoriasis to measure serum vaspin levels and to genotype vaspin gene polymorphisms (SERPNA12). Blood samples will be taken for serum protein measurement and DNA analysis, and clinical information including treatment history will be recorded. Eligible participants are newly diagnosed patients or those off treatment for at least six months, while individuals with pregnancy, lactation, chronic systemic disease, malignancy, or other inflammatory conditions are excluded. Data analysis will look for correlations between genotype variants, serum vaspin concentrations, and clinical features of psoriasis.
Why it matters
Potential benefit: If a link is found, it could help identify genetic markers tied to disease features or metabolic risks and guide future personalized research or risk stratification.
How similar studies have gone: Prior studies have linked adipokines to psoriasis and cardiometabolic risk, but research specifically on vaspin gene polymorphisms is limited and has yielded mixed or preliminary results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Newly diagnosed cases or stopped treatment of at least 6 months of psoriasis patients. * Pateints with any age and gender. Exclusion Criteria: * Pregnancy and lactation. * Patients with chronic diseases: cardiac diseases, hepatic disorders, chronic renal failure or malignancies. * Patients with associated inflammatory disease such as infections and autoimmune diseases.
Where it's running
-
Aswan University Hospital
Aswān, Egypt Recruiting
Study contacts
- Study coordinator: Ola Mahmoud Samy Mohamed, MSC
- Email: olaelqousy@gmail.com
- Phone: +201025592922
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.