Vascular changes after endophthalmitis
Official title: Vascular Changes Associated With Endophthalmitis.
Run by Asociación para Evitar la Ceguera en México · NCT07175311 · Data updated 2026-11-12
We will see if multimodal eye imaging can reveal blood-vessel changes in adults who have had endophthalmitis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 71 (estimated) |
| Sponsor | Asociación para Evitar la Ceguera en México Academic / other |
| Locations | 1 site (Mexico City) |
| Status | Recruiting |
| Started | November 1, 2024 |
| Main results expected | February 2026 |
| Study ends | March 1, 2026 |
| Registry record updated | September 16, 2025 |
| Trial ID | NCT07175311 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18 and older) with a history of exogenous or endogenous endophthalmitis who meet the resolution criteria and can undergo multimodal imaging and give informed consent.
✕Probably not a fit
Patients under 18, those who do not meet the resolution criteria, or those unable to undergo or tolerate the required imaging are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, longitudinal, observational, and descriptive project enrolling patients from the retina and vitreous service at Asociación para Evitar la Ceguera en México. Participants who meet the Mexican Endophthalmitis Study Group resolution criteria and have given consent will undergo multimodal imaging during diagnosis and at follow-up, including fluorescein angiography one week and one month after resolution. The team will catalog imaging findings into a photo library and characterize vascular patterns to help distinguish changes from immune response, drug toxicity, or ischemia. Data collection includes clinical history, visual acuity, intraocular pressure, B-mode ultrasound or culture results, and serial imaging.
Why it matters
Potential benefit: If successful, this could help clinicians detect and distinguish vascular causes of vision loss earlier and guide more targeted treatments to improve outcomes.
How similar studies have gone: Case reports and small series have described vascular changes on multimodal imaging in endophthalmitis, but prospective, systematic photo libraries are limited and this approach is not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a history of endophthalmitis Diagnosis of Endophthalmitis * Clinical symptoms: Pain, decrease in visual acuity, anterior chamber cells and/or vitreous turbidity, corneal edema, conjunctival hyperemia * Laboratory studies: B-mode USG and or positive culture * Patients who meet the endophthalmitis resolution criteria of the Mexican Endophthalmitis Study Group * Patients with previously signed informed consent Exclusion Criteria: * Patients who have not signed the informed consent * Patients under 18 years. * Patients with endophthalmitis who do not meet the resolution criteria of the Mexican Endophthalmitis Study Group
Where it's running
-
Hospital Asociación Para Evitar la Ceguera en México I.A.P.
Mexico City, Mexico Recruiting
Study contacts
- Principal investigator: Raul Velez Montoya, MD — Asociación para Evitar la Ceguera en México
- Study coordinator: Raúl Velez Montoya, MD
- Email: rvelezmx@yahoo.com
- Phone: (52) 55 5436 7335
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.