VALVE-AI: AI-ECG screening to find moderate or severe heart valve disease.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized controlled trial, adult outpatients aged 60–85 receiving a standard 12-lead ECG have each ECG analyzed by a validated deep-learning AI that classifies risk for significant valvular heart disease. Participants flagged as high-risk by the AI are randomized to either receive transthoracic echocardiography (experimental arm) or continue usual clinical care without routine echo prompted by the AI result (control arm), while low-risk participants receive routine care. The primary outcome is the rate of newly detected moderate or severe VHD within 90 days post-randomization. Secondary outcomes include time to diagnosis, downstream management changes, and feasibility of integrating AI-ECG screening into outpatient workflows.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least one 12-lead ECG within 1 year
* Age 60-85 years of age

Exclusion Criteria:

* Documented echocardiography within 3 years before indexed ECG
* Any known valvular heart disease
* History of any valvular surgery
* Post-heart transplant

Where it's running

• Tri-Service General Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Chin Lin
• Email: xup6fup0629@gmail.com
• Phone: +886-2-8792-3100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• Heart sound signals to detect valve and artery disease early

  This observational study tests whether a new digital stethoscope-like device can pick up heart sound patterns to detect valvular or coronary artery disease earlier in people who are already getting heart imaging.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07496775

• Pulmonary Vascular Disease in Valvular Heart Disease: How Valve Procedures Affect Blood Flow

  This study tests how blood flow in the lungs changes in adults with left-sided valve disease who are having valve surgery and looks to see if patterns can predict reversibility of tricuspid regurgitation and right heart dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07483203

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• MMVD: A Multicenter Registry to Understand Multiple and Mixed Valvular Heart Disease

  This study tests how common MMVD is, what imaging and management practices are used, and what factors influence outcomes in adults with two or more valve issues.

  Recruiting at 2 sites French Cardiology Society · Lille and 1 other locations · NCT07176507

• Aortic valve sizing: comparing CT scan measurements with measurements taken during surgery for people having surgical aortic valve replacement

  This will see if CT scan measurements match the aortic valve sizes surgeons measure during surgical aortic valve replacement in adults with severe aortic stenosis.

  Recruiting Maria Cecilia Hospital · Cotignola, Ravenna · NCT07125469

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.