Values-based intervention to support Veterans in early opioid treatment

A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment

Not applicable Interventional VA Office of Research and Development · NCT05189223

This study is testing a new support program for Veterans starting treatment for opioid use disorder to see if it helps them connect better with others and feel more at home in their communities.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years and up
SexAll
SponsorVA Office of Research and Development Federal
Locations1 site (Bedford, Massachusetts)
Trial IDNCT05189223 on ClinicalTrials.gov

What this trial studies

This project aims to develop and test a brief, values-based intervention designed to enhance interpersonal functioning and community integration for Veterans undergoing early treatment for opioid use disorder (OUD) with buprenorphine. The study will unfold in three phases: the first phase focuses on creating a treatment manual informed by interviews with Veterans and VA providers, while the second phase involves an open pilot trial with a small group of Veterans to refine the intervention and study protocol. The ultimate goal is to gather data that will inform the feasibility of a larger randomized controlled trial.

Who should consider this trial

Good fit: Ideal candidates for this study are Veterans diagnosed with moderate to severe opioid use disorder who have recently initiated buprenorphine treatment.

Not a fit: Patients with active psychosis, severe cognitive impairment, or those requiring detoxification may not benefit from this intervention.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the quality of life and recovery outcomes for Veterans in early buprenorphine treatment.

How similar studies have performed: While this approach is innovative, similar interventions targeting community integration and interpersonal functioning in addiction treatment have shown promise in other populations.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Meets current Diagnostic and Statistical Manual - 5th Edition criteria for moderate to severe opioid use disorder
* Within 12 weeks of initiating buprenorphine, methadone, or naltrexone treatment for opioid use disorder following at least 2 months without treatment
* Competent to provide written informed consent

Exclusion Criteria:

* Evidence of active psychosis or mania
* Suicidality requiring inpatient hospitalization
* Active substance use requiring detoxification
* Cognitive impairment that would interfere with study participation

Where this trial is running

Bedford, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dependence, OpioidCommunity integrationVeteransBuprenorphine
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.