Validation of Adaptive Radiotherapy for Head and Neck Tumors
Adaptive Radiotherapy in the Treatment of Patients With a Histologically Confirmed Malignant Tumor in the Head and Neck Region: Prospective Validation of ART in Patients With HNT (Prospektive Validierung Der ART Bei Patientinnen Und Patienen Mit Kopf-Hals Tumoren,)
This study is testing if a new way of giving radiation therapy that adjusts to changes in head and neck tumors during treatment can help patients get better results.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Essen Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Essen, Germany / NRW) |
| Trial ID | NCT06214611 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of adaptive radiotherapy (ART) in patients with head and neck tumors, focusing on how anatomical changes during treatment can affect radiation delivery. By utilizing advanced techniques such as image-guided radiotherapy (IGRT) and online adaptive re-planning, the study aims to optimize treatment plans for individual patients. The goal is to identify which patients will benefit most from ART and to assess whether this method can reduce the planning target volume margins compared to traditional IGRT. The research is conducted at the University Hospital Essen, utilizing the ETHOS linear accelerator for real-time treatment adjustments.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with head and neck tumors who are eligible for radiotherapy and have an ECOG performance status of 0-1.
Not a fit: Patients who are pregnant or have a performance status worse than ECOG 1 may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized radiation treatment for patients with head and neck cancer, potentially improving outcomes and reducing side effects.
How similar studies have performed: Previous studies have shown promise in the use of adaptive radiotherapy, but this specific approach is being evaluated for its unique application in head and neck cancer.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ECOG 0-1 2. Histopathology confirmation 3. Compliance 4. Tumor in the head and neck region 5. Indication for radiotherapy Exclusion Criteria: 1\. Pregnancy
Where this trial is running
Essen, Germany / NRW
- Department for Radiotherapy, University Hospital Essen, National Center for Tumor Diseases (NCT) West — Essen, Germany / NRW, Germany (Recruiting)
Study contacts
- Study coordinator: Maja PD Dr. med. Guberina, PD Dr. med. (MD), specialist
- Email: maja.guberina@uk-essen.de
- Phone: +492017232321
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.