Validating staging systems for amyotrophic lateral sclerosis
Staging System in Amyotrophic Lateral Sclerosis
This study is trying to see if two new ways to track the progression of ALS can help doctors understand how the disease affects patients over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Sex | All |
| Sponsor | University Hospital, Limoges Academic / other |
| Locations | 2 sites (Limoges and 1 other locations) |
| Trial ID | NCT04858555 on ClinicalTrials.gov |
What this trial studies
This study aims to validate two proposed staging systems for amyotrophic lateral sclerosis (ALS) based on clinical milestones and to assess the role of neurofilament biomarkers in predicting neurological decline. It will involve an independent cohort of ALS patients followed at the ALS expert center in Limoges, France. The research seeks to improve understanding of ALS progression and disease activity through accurate staging and biomarker analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with amyotrophic lateral sclerosis who were recruited between 2007 and 2016 or those prospectively recruited by the ALS expert center in Limoges.
Not a fit: Patients with a history of neurosurgical operations, recent neurotrauma, peripheral neuropathies, or ALS/frontotemporal dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved staging and management of ALS, enhancing patient care and treatment outcomes.
How similar studies have performed: Previous studies have tested these staging systems in independent cohorts, but results were inconsistent, indicating the need for further validation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ALS cases recruited for retrospectively (between) 2007 to 2016 for the retrospective cohort * ALS cases recruited for prospectively by the ALS expert center of Limoges for one year. Exclusion Criteria: * Previous neurosurgical operations * A recent history of neurotrauma * Peripheral neuropathies * ALS/frontotemporal dementia (ALS/FTD)
Where this trial is running
Limoges and 1 other locations
- Limoges University Hospital — Limoges, France (Recruiting)
- Tours University Hospital — Tours, France (Recruiting)
Study contacts
- Study coordinator: Philippe Couratier, Pr
- Email: Philippe.Couratier@chu-limoges.fr
- Phone: 00335 55 05 65 61
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.