Validating a risk score for MDRGNB infection in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective multicenter study enrolls adult ICU patients from 11 centers to validate a risk prediction model for MDRGNB infection using data available within 24 hours of ICU admission. Predictions are generated from routine clinical data without altering patient care, and the study analyzes discrimination, calibration, and net benefit at a predefined threshold. The primary goal is to see how well the model predicts infection risk in real-world ICU settings and to determine its potential clinical usefulness. Eligible participants are adults 18 or older with ICU stays of at least 48 hours and available microbiology data, with key variables extractable from electronic records.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* ICU stay ≥48 hours;
* At least one clinical microbiological specimen collected and submitted for testing within 48 hours of ICU admission, with the first submission time designated as the index time;
* Core predictive variables of the model extractable from electronic medical records or laboratory information systems.

Exclusion Criteria:

* For patients with multiple ICU admissions, only the first ICU stay was retained;
* Missing or indeterminate primary outcome;
* Missing key predictive variables that could not be handled according to prespecified rules.

Where it's running

• Nanjing Drum Tower Hospital
  Nanjing, Jiangsu, China Recruiting
• Zhejiang Hospital
  Hangzhou, China Recruiting
• Guangxi Provincial Tumor Hospital
  Nanning, China Recruiting
• Shanghai Ruijin Hospital
  Shanghai, China Recruiting
• Ankang People's Hospital
  Ankang, China Not yet recruiting
• Sinopharm Tongmei General Hospital
  Datong, China Not yet recruiting

Study contacts

• Study coordinator: Dayu Chen, Pharmacist in Charge, PharmD
• Email: cdy_pharmacy@njglyy.com
• Phone: +86-025-83106666-60924

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.