Vaginal ultrasound-guided ethanol sclerotherapy versus laparoscopic cystectomy for ovarian endometriomas.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a non-inferiority interventional comparison of vaginal ultrasound-guided ethanol sclerotherapy and standard laparoscopic cystectomy for ovarian endometriomas. Women meeting age and imaging criteria receive one of the two procedures and are followed over time to compare pain recurrence, pregnancy outcomes, and ovarian reserve measures. Key eligibility includes a single endometrioma 3–10 cm with endometriosis-related pain (VAS >30 mm). The trial is carried out at the gynecology department of Assistance Publique–Hôpitaux de Marseille.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 45
* Endometrioma diagnosed by endovaginal ultrasound or MRI (examinations carried out by a radiologist or gynaecologist) with a typical appearance and whose largest diameter is between 3 and 10 centimetres.
* Pain (dysmenorrhoea or chronic pelvic pain) with a VAS greater than 30 millimetres, assessed by the question "Indicate the subjective level of your endometriosis-related pain over the last 4 weeks".

Exclusion Criteria:

* Inability to speak French
* Refusal to take part in the study
* Risk factors for impaired ovarian reserve:
* Ovarian reserve already low (AMH \<1,5ng/ml or Antral follicle count \< 7 on the contralateral ovary
* Bilateral or multiple endometriomas (two or more endometriomas greater than 3 centimetres in diameter).
* Previous cystectomy
* Previous major peritoneal surgery causing adhesions.
* Contraindication to sclerotherapy : allergy to ethanol
* Contraindications to general anaesthesia
* Pregnant women, women in labour and nursing mothers

Where it's running

• gynecology department APHM
  Marseille, France, France Recruiting

Study contacts

• Principal investigator: Antoine NETTER — Assistance Publique - Hôpitaux de Marseille
• Study coordinator: Claire MORANDO
• Email: claire.morando@ap-hm.fr ; promotion.interne@ap-hm.fr
• Phone: 0491382183

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Alcohol sclerotherapy for pelvic pain and quality of life in ovarian endometrioma

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.