Vacuum Compression Therapy for Venous Leg Ulcers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares vacuum compression therapy plus standard wound care versus standard wound care alone in adults with chronic venous leg ulcers. Local tissue oxygenation is measured on both the affected and contralateral limbs, and wound healing is tracked over time using clinical measurements and digital planimetry with Fiji software. The aim is to determine if VCT can improve microvascular oxygen delivery and accelerate wound closure compared with standard care. Inter-group and intra-patient controls help separate treatment effects from systemic healing variation. TcPO2, wound dimensions, and photographic analyses are used to quantify outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients (≥18 years) with chronic lower limb ulcers of venous etiology that had persisted despite appropriate standard therapy and showed no significant signs of healing progression over a one-month period

Exclusion Criteria:

* age under 18 years,
* inability to cooperate with study procedures,
* clinically significant infection requiring systemic antibiotic therapy,
* active oncological disease, severe uncontrolled pain, and
* any contraindications to vacuum compression therapy

Where it's running

• Department of Dermatology, University Hospital Ostrava
  Ostrava, Czechia Recruiting

Study contacts

• Principal investigator: Lenka Krupová, Mgr., Ph.D. — Department of Dermatology, University Hospital Ostrava, Ostrava, Czech Republic
• Study coordinator: Lenka Krupová, Mgr., Ph.D.
• Email: lenka.krupova@fno.cz
• Phone: +420 737208139

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using music therapy to reduce pain from leg ulcer care

  This study tests if music therapy can help reduce pain for adults getting treatment for leg ulcers.

  Recruiting University Hospital Center of Martinique · Fort-de-France · NCT06153589

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.