Vaccines for mothers and their children to improve health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of administering the measles and BCG vaccines to women of childbearing age and their children in Guinea-Bissau. It aims to determine how these vaccines can enhance immunity against measles and improve overall health outcomes for both mothers and infants. The study will randomly assign 2400 women to receive either the BCG vaccine, measles vaccine, or a placebo, and their children will also be randomized to receive an early measles vaccine or placebo. The research will assess the effectiveness of different vaccination schedules on immune responses and health metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female women in the fertile age
* Non-pregnant
* HIV-negative
* Living in the BHP HDSS study area
* Delivered a child that has reached 12 months of age
* Currently not using contraceptives.

Exclusion Criteria:

* Positive pregnancy test
* Positive HIV test
* Tuberculosis (previous or current)
* Immunodeficiency
* Cancer within the last 2 years
* Mid-upper-arm-circumference\<200
* Acute ongoing infection

Where it's running

• Bandim Health Project
  Bissau, Bissau Codex, Guinea-Bissau Recruiting

Study contacts

• Principal investigator: Christine Benn, DMSc — University of Southern Denmark
• Study coordinator: Isaquel da Silva, MD
• Email: isabarsila@gmail.com
• Phone: +245966654873

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.