Uterus transplantation from a deceased donor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial focuses on uterus transplantation for women with Mayer-Rokitansky-Küster-Hauser syndrome, a condition that causes infertility due to the absence of a uterus. Participants will undergo screening and in vitro fertilization (IVF) to freeze embryos before the transplantation procedure. The study aims to facilitate pregnancy and, after childbirth, the removal of the transplanted uterus. The approach involves utilizing a multi-organ donor to provide the uterus for transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female with Maier-Rokitansky-Kuster-Hauser syndrome
* Mucosal neovagina of at least 7 cm
* In a stable relationship for at least 1 year
* Child wish
* Good renal function (and presence of both kidneys)
* Psychologically stable and compliant
* At least 8 frozen embryos after IVF/intracytoplasmic sperm injection \[ICSI\]
* Living in Belgium and a good health insurance
* Willing and able to provide informed consent

Exclusion Criteria:

* Major pelvic surgery
* Major chronic illnesses
* Other risk factors or malignancies
* BMI \> 30

Where it's running

• Ghent University Hospital - Women's Clinic
  Ghent, Belgium Recruiting

Study contacts

• Study coordinator: Steven Weyers, MD, PhD
• Email: steven.weyers@uzgent.be
• Phone: +3293325446

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.