Uterus transplantation from a deceased donor
Uterus Transplantation From a Multi-organ Donor: A Prospective Trial
This study is testing if women with Mayer-Rokitansky-Küster-Hauser syndrome can become pregnant by receiving a uterus from a deceased donor and using frozen embryos.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 38 Years |
| Sex | Female |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Trial ID | NCT03252795 on ClinicalTrials.gov |
What this trial studies
This clinical trial focuses on uterus transplantation for women with Mayer-Rokitansky-Küster-Hauser syndrome, a condition that causes infertility due to the absence of a uterus. Participants will undergo screening and in vitro fertilization (IVF) to freeze embryos before the transplantation procedure. The study aims to facilitate pregnancy and, after childbirth, the removal of the transplanted uterus. The approach involves utilizing a multi-organ donor to provide the uterus for transplantation.
Who should consider this trial
Good fit: Ideal candidates are females diagnosed with Mayer-Rokitansky-Küster-Hauser syndrome who have a stable relationship and meet specific health criteria.
Not a fit: Patients with major chronic illnesses, significant pelvic surgery history, or a BMI over 30 may not benefit from this study.
Why it matters
Potential benefit: If successful, this procedure could enable women with specific infertility conditions to achieve pregnancy and childbirth.
How similar studies have performed: While uterus transplantation is a relatively novel approach, previous studies have shown promising outcomes in similar cases, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female with Maier-Rokitansky-Kuster-Hauser syndrome * Mucosal neovagina of at least 7 cm * In a stable relationship for at least 1 year * Child wish * Good renal function (and presence of both kidneys) * Psychologically stable and compliant * At least 8 frozen embryos after IVF/intracytoplasmic sperm injection \[ICSI\] * Living in Belgium and a good health insurance * Willing and able to provide informed consent Exclusion Criteria: * Major pelvic surgery * Major chronic illnesses * Other risk factors or malignancies * BMI \> 30
Where this trial is running
Ghent
- Ghent University Hospital - Women's Clinic — Ghent, Belgium (Recruiting)
Study contacts
- Study coordinator: Steven Weyers, MD, PhD
- Email: steven.weyers@uzgent.be
- Phone: +3293325446
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.