Uterine transplantation from living donors for women with MRKH syndrome
Official title: Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
Run by Hopital Foch · NCT03689842 · Data updated 2026-11-12
This study is testing if women with MRKH syndrome can successfully receive a uterus transplant from living donors to help them achieve pregnancy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 20 (estimated) |
| Sponsor | Hopital Foch Academic / other |
| Locations | 1 site (Suresnes) |
| Status | Recruiting |
| Started | December 14, 2017 |
| Main results expected | December 14, 2027 |
| Study ends | December 14, 2034 |
| Registry record updated | March 7, 2025 |
| Trial ID | NCT03689842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 to 38 with MRKH type I syndrome who are in stable relationships and have a desire for pregnancy.
✕Probably not a fit
Patients with severe male infertility issues or significant medical history that complicates surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the feasibility of uterine transplantation from living donors in women diagnosed with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a condition characterized by the absence of a uterus. The trial will involve 10 patients who will receive a uterus transplant and will be monitored for both the anatomical and functional outcomes of the transplant, as well as the safety and psychological well-being of the living donors. The ultimate goal is to achieve a successful pregnancy following the transplantation procedure.
Why it matters
Potential benefit: If successful, this approach could provide a viable option for women with MRKH syndrome to achieve pregnancy.
How similar studies have gone: While uterine transplantation is a novel approach, there have been successful cases in other countries, indicating potential for success in this study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Graft recipient is a patient with Mayer-Rokitansky-Küster-Hauser Type I Uterine Vaginal Agenesis (without renal, cardiac and bone malformations): * Being aged between 18 and 38 years old * In stable couple, with a pregnancy project, favorable psychological evaluation * No history of cancer and transfusion The living donor is a woman related to the Graft recipient with * Absence of comorbidity (neurological, nephro-urological pathology, infectious, psychiatric or psychological pathology) * Absence of uterine surgery, abdomino-pelvic major pathology history Exclusion Criteria: Graft recipient: * Extreme oligo-astheno-spermia and azoospermia in the husband * History of abdominopelvic surgery excluding uncomplicated appendectomy; vaginal residue not allowing anastomosis Living donor : * Known thromboembolic risk factor * No Compatibility with the recipient (group, rhesus, HLA)
Where it's running
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Hopital Foch
Suresnes, France Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Uterine transplant for women with infertility due to absence of uterus
This study is testing if a uterine transplant from a donor can help women with no uterus due to infertility become pregnant and have a baby.
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Uterus transplantation from a deceased donor
This study is testing if women with Mayer-Rokitansky-Küster-Hauser syndrome can become pregnant by receiving a uterus from a deceased donor and using frozen embryos.
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Understanding the genetic causes of Mayer-Rokitansky-Kuster-Hauser syndrome
This study is trying to find out the genetic causes of Mayer-Rokitansky-Kuster-Hauser syndrome by looking at blood samples from patients and their healthy family members.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.