Uterine artery ligation versus pericervical tourniquet to reduce bleeding during open myomectomy
Official title: Bilateral Uterine Artery Ligation Versus Pericervical Mechanical Tourniquet Application in Reducing Intraoperative Blood Loss During Transabdominal Myomectomy.
Run by Cairo University · NCT07526311 · Data updated 2026-11-12
This trial will test whether tying the uterine arteries or using a pericervical tourniquet better reduces blood loss during open myomectomy for women with symptomatic uterine fibroids.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 48 Years |
| Sex | Women only |
| Enrollment | 40 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Al-Manial) |
| Status | Recruiting |
| Started | April 10, 2026 |
| Main results expected | March 10, 2027 |
| Study ends | April 10, 2027 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07526311 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 25–48 with symptomatic intramural uterine fibroids (FIGO 3–6), BMI under 35 kg/m², preoperative hemoglobin ≥10 g/dL, and scheduled for elective transabdominal myomectomy who can give informed consent.
✕Probably not a fit
Patients with submucosal, intracavitary, pedunculated, cervical, or adnexal myomas, prior uterine surgery, bleeding disorders, anticoagulant use, BMI ≥35 kg/m², or preoperative hemoglobin <10 g/dL are not eligible and therefore unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized comparison of two vascular control techniques—bilateral uterine artery ligation and pericervical mechanical tourniquet—applied during elective transabdominal myomectomy. Women with symptomatic intramural fibroids (FIGO types 3–6) who meet inclusion criteria are randomized to one technique before myoma enucleation. The study measures intraoperative blood loss and surgical safety outcomes, including complications and need for transfusion. The trial is conducted at the Department of Obstetrics and Gynecology, Kasr Al‑Ainy Hospital, Cairo University.
Why it matters
Potential benefit: If successful, the preferred technique could reduce intraoperative blood loss, lower transfusion rates, and make myomectomy safer while preserving the uterus.
How similar studies have gone: Both uterine artery ligation and pericervical tourniquet are used in practice and small series suggest each can reduce bleeding, but few randomized head‑to‑head trials have directly compared them.
Who can join: the full rules
Show full inclusion / exclusion criteria
* Inclusion Criteria: * Female participants aged 25 to 48 years * Body mass index less than 35 kg/m² * Symptomatic uterine myomas requiring surgical treatment * Intramural myomas classified as FIGO types 3 to 6 * Diagnosis confirmed by transvaginal ultrasound and/or magnetic resonance imaging * Maximum diameter of the largest myoma 20 cm or less * Scheduled for elective transabdominal myomectomy * Able and willing to provide written informed consent * Exclusion Criteria: * Submucosal, intracavitary, pedunculated subserosal, cervical, or adnexal myomas * FIGO types 0, 1, 2, 7, or 8 myomas * History of pelvic inflammatory disease or peritonitis * Previous abdominal or pelvic surgery for non-obstetric causes * Previous uterine surgery * Use of hormonal therapy within the previous 3 months * Known bleeding disorder * Use of anticoagulant or antiplatelet therapy * Preoperative hemoglobin less than 10 g/dL * Body mass index 35 kg/m² or greater * Intraoperative conversion from myomectomy to hysterectomy
Where it's running
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Cairo University
Cairo, Al-Manial, Egypt Recruiting
Study contacts
- Study coordinator: Maged Elmohamady Rashedy, MD
- Email: Magedalmohamady50@gmail.com
- Phone: 01090013685
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.