Using zoledronic acid-loaded bone cement to reduce recurrence of giant cell bone tumors after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of zoledronic acid-loaded bone cement as an adjuvant therapy to decrease local recurrence rates in patients with giant cell tumors of the bone following intralesional curettage surgery. The study compares the outcomes of patients receiving this specialized bone cement to those receiving traditional gentamicin PMMA bone cement. Additionally, it evaluates secondary outcomes such as functional improvement and surgery-related complications. The trial aims to provide insights into the potential benefits of local drug delivery in surgical oncology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with primary resectable GCT of bone
* lesion amenable to reconstruction (intralesional curettage) defined as having at least one intact column of bone after removal
* no previous systemic bisphosphonate or denosumab therapy
* with expected longer than 18 months of survival time
* sign the informed consent form

Exclusion Criteria:

* patients with recurrent GCT or extensive GCT which is impossible or inappropriate to use curettage surgery due to its "unresectable" nature.
* conduct unexpected surgery at other center
* the primary goal for surgery is revision
* patient conduct en-bloc/wide resection instead of curettage surgery
* patient can not conduct self-assessment during follow up
* difficulty in complete postoperative follow-up
* previous use of bisphosphonate/ZOL or denosumab drug
* patients have participated in similar research projects
* refused to sign informed consent

Where it's running

• The Second Affiliated Hospital of Zhejiang University
  Hangzhou, China Recruiting

Study contacts

• Study coordinator: Meng Liu, MD
• Email: liumeng80@163.com
• Phone: 13515711791

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using bisphosphonate to reduce tumor recurrence in bone tumors

  This study is testing if using a special bone cement with bisphosphonate during surgery can help prevent giant cell tumors in bones from coming back and improve recovery compared to regular surgery alone.

  Recruiting at 12 sites Phase 3 St. Louis University · Los Angeles, California and 15 other locations · NCT03295981

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.