Using zinc oxide ozonated olive oil for treating dental pulp issues in children
Zinc Oxide Ozonated Oil Versus Modified Triple Antibiotic Paste as a Lesion Sterilization and Tissue Repair Technique in Primary Molars
This study is testing if a new treatment using zinc oxide-ozonated olive oil can help children aged 4-7 with dental pulp problems in their baby teeth better than a common antibiotic paste.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 4 Years to 7 Years |
| Sex | All |
| Sponsor | Tanta University Academic / other |
| Locations | 2 sites (Tanta, Gharbia Governorate and 1 other locations) |
| Trial ID | NCT06854744 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of zinc oxide-ozonated olive oil (ZnO-OO) compared to Modified Triple Antibiotic Paste (MTAP) in treating pulp necrosis in primary molars. The research focuses on children aged 4-7 years who exhibit signs of pulp disease, aiming to preserve primary teeth and prevent complications associated with early tooth loss. The methodology includes clinical assessments and radiographic evaluations to determine the success of the treatments in promoting lesion sterilization and tissue repair.
Who should consider this trial
Good fit: Ideal candidates for this study are cooperative children aged 4-7 years with signs of pulp necrosis in their primary molars.
Not a fit: Patients with non-restorable teeth or significant root resorption are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could improve dental health outcomes in children by effectively managing pulpitis and preserving primary teeth.
How similar studies have performed: While the use of ozonated oils in dental treatments is emerging, this specific approach has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1- Cooperative patients in the age group of (4-7) years with no associated systemic illness. 2- Bilateral mandibular primary molars showing signs and symptoms of pulp necrosis or chronic pulp infection with/without hemorrhage, suppuration, or purulence. 3- Spontaneous pain or tenderness to percussion. 4- Presence of chronic apical abscess, sinus tract, or grade I mobility. 5-The tooth should be restorable. 6- Radiographic characteristics are: 1. Widening of Periodontal ligament space. 2. Radicular involvement. 3. Furcation involvement less than or equal to half of the shortest root in the vertical dimension \- Exclusion Criteria: Exclusion criteria : 1. Physiologic root resorption is more than one-third of its length. 2. Excessive internal resorption. 3. Non-restorable teeth exhibiting greater than grade I mobility. 4. Perforation into the bifurcation. 5. Any underlying pathological lesion. 6. Any previous history of allergy to the antibiotics used in the study. -
Where this trial is running
Tanta, Gharbia Governorate and 1 other locations
- Faculty of dentistry Tanta university — Tanta, Gharbia Governorate, Egypt (Recruiting)
- Nouran Esmail Mohamed Shalaby — Menouf, Egypt (Recruiting)
Study contacts
- Principal investigator: Shaimaa Sh El-Desokey, Professor — Faculty of dentistry Tanta university , tanta
- Study coordinator: nouran esmail shalaby, master
- Email: PG_167682@dent.tanta.edu.eg
- Phone: +20 01018710314
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.