Using vitamin C to prevent pain syndrome after wrist fractures
The Role of Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures: a Randomized Control Study
PHASE4 · Damascus University · NCT05842395
This study is testing if taking vitamin C can help prevent painful complications after wrist fractures in adults.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 220 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Damascus University (other) |
| Locations | 1 site (Damascus) |
| Trial ID | NCT05842395 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of vitamin C supplementation in preventing Complex Regional Pain Syndrome (CRPS) type 1 following distal radius fractures. It is a multicenter, randomized, controlled trial conducted in two hospitals in Damascus, Syria. Participants aged 18 and older with specific types of distal radius fractures will be randomly assigned to receive either a placebo or 1g of vitamin C daily for 90 days, starting on the day of their fracture treatment. The study aims to determine if vitamin C can reduce the incidence of CRPS, a painful complication that can arise after such injuries.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have sustained specific types of distal radius fractures.
Not a fit: Patients with multiple trauma, neurovascular injuries, or those requiring surgical intervention for their fractures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a simple and effective method to prevent CRPS in patients with distal radius fractures.
How similar studies have performed: While the use of vitamin C for CRPS prevention is suggested in literature, this specific approach is novel and has not been extensively tested in clinical trials.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * participants who were injured with distal radius fractures and classified using the AO classification as A1, A2, A3, B1, and C1. Exclusion Criteria: * Multiple trauma patients. * patients who have neurovascular injuries. * Patients with fractures are classified using the AO classification as B2, B3, C2, and C3. * Patients who are eligible for open reduction internal fixation of their fractures. * Patients with chronic or acute renal failure. * Patients who already take multi-vitamin supplementation or vitamin C supplementation.
Where this trial is running
Damascus
- Damascus University — Damascus, Syrian Arab Republic (RECRUITING)
Study contacts
- Principal investigator: doried Diri, MD — Damascus university - faculty of medicine - department of surgery
- Study coordinator: jaber ibrahim, MD PHD
- Email: drjaberhibrahim@gmail.com
- Phone: 944411241
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Distal Radius Fracture, Vitamine c, Prophylaxis, distal radius fractures, vitamine c, prophylaxis