Using vitamin C to improve lung function in children of pregnant smokers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the long-term effects of prenatal vitamin C supplementation on the pulmonary function of children born to mothers who smoked during pregnancy. Following up on the original VCSIP trial, the study will compare airway function tests and the occurrence of wheezing in children at 10 years of age, based on whether their mothers received vitamin C or a placebo during pregnancy. The study will also include advanced imaging techniques to analyze lung structure and DNA methylation differences between the two groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the original VCSIP study

Exclusion Criteria:

* participants who specifically withdraw consent

Where it's running

• Indiana University
  Indianapolis, Indiana, United States Recruiting
• Oregon Health and Science University (OHSU)
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Cindy McEvoy, MD, MCR — Oregon Health and Science University
• Study coordinator: Cindy McEvoy, MD, MCR
• Email: mcevoyc@ohsu.edu
• Phone: 503-494-0223

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.